Skip to main content

Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia.

Publication ,  Journal Article
Athavale, K; Claure, N; D'Ugard, C; Everett, R; Swaminathan, S; Bancalari, E
Published in: J Perinatol
December 2004

BACKGROUND: Inhaled nitric oxide (iNO) reduces pulmonary vascular resistance by preferential vasodilation in ventilated lung units. In experimental animals, iNO also reduces airway resistance by smooth muscle relaxation. Hence, there may be a therapeutic role for iNO in evolving bronchopulmonary dysplasia (BPD). OBJECTIVE: To evaluate the acute effects of low-dose iNO on lung mechanics, ventilation distribution, oxygenation, and cardiac function in preterm infants with evolving BPD. METHODS: Measurements of lung compliance (C(L)), airway resistance (R(L)), ventilation-distribution (N(2) clearance in multiple-breath washout), oxygenation (SpO(2)), left ventricular ejection fraction (LVEF) and right ventricular shortening fraction were obtained before and during 2 hours of iNO (10 ppm) in a group of ventilated preterm infants with evolving BPD. RESULTS: A total of 13 preterm infants with (mean+/-SD) BW: 663.8+/-116 g, GA: 24.9+/-1.2 weeks, age: 32+/-14 days, mean airway pressure: 6.7+/-0.9 cmH(2)O and fraction of inspired oxygen: 0.35+/-0.06 were studied. iNO did not affect C(L), R(L) or N(2) clearance. There was a small increase in LVEF. Mean SpO(2) remained unchanged, but the duration of spontaneous hypoxemic episodes increased during iNO. CONCLUSION: Low-dose iNO had no acute effects on lung function, cardiac function and oxygenation in evolving BPD.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

December 2004

Volume

24

Issue

12

Start / End Page

769 / 774

Location

United States

Related Subject Headings

  • Ventricular Function, Right
  • Respiratory Mechanics
  • Pulmonary Ventilation
  • Pediatrics
  • Oxygen
  • Oximetry
  • Nitric Oxide
  • Male
  • Infant, Premature
  • Infant, Newborn
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Athavale, K., Claure, N., D’Ugard, C., Everett, R., Swaminathan, S., & Bancalari, E. (2004). Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia. J Perinatol, 24(12), 769–774. https://doi.org/10.1038/sj.jp.7211216
Athavale, Kamlesh, Nelson Claure, Carmen D’Ugard, Ruth Everett, Sethuraman Swaminathan, and Eduardo Bancalari. “Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia.J Perinatol 24, no. 12 (December 2004): 769–74. https://doi.org/10.1038/sj.jp.7211216.
Athavale K, Claure N, D’Ugard C, Everett R, Swaminathan S, Bancalari E. Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia. J Perinatol. 2004 Dec;24(12):769–74.
Athavale, Kamlesh, et al. “Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia.J Perinatol, vol. 24, no. 12, Dec. 2004, pp. 769–74. Pubmed, doi:10.1038/sj.jp.7211216.
Athavale K, Claure N, D’Ugard C, Everett R, Swaminathan S, Bancalari E. Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia. J Perinatol. 2004 Dec;24(12):769–774.

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

December 2004

Volume

24

Issue

12

Start / End Page

769 / 774

Location

United States

Related Subject Headings

  • Ventricular Function, Right
  • Respiratory Mechanics
  • Pulmonary Ventilation
  • Pediatrics
  • Oxygen
  • Oximetry
  • Nitric Oxide
  • Male
  • Infant, Premature
  • Infant, Newborn