Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.
Publication
, Journal Article
Need, AC; Attix, DK; McEvoy, JM; Cirulli, ET; Linney, KN; Wagoner, AP; Gumbs, CE; Giegling, I; Möller, H-J; Francks, C; Muglia, P; Roses, A ...
Published in: Am J Med Genet B Neuropsychiatr Genet
July 5, 2008
It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory.
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Published In
Am J Med Genet B Neuropsychiatr Genet
DOI
EISSN
1552-485X
Publication Date
July 5, 2008
Volume
147B
Issue
5
Start / End Page
667 / 668
Location
United States
Related Subject Headings
- White People
- Reproducibility of Results
- Proteins
- Polymorphism, Single Nucleotide
- Phosphoproteins
- Memory
- Intracellular Signaling Peptides and Proteins
- Humans
- Europe
- Cohort Studies
Citation
APA
Chicago
ICMJE
MLA
NLM
Need, A. C., Attix, D. K., McEvoy, J. M., Cirulli, E. T., Linney, K. N., Wagoner, A. P., … Goldstein, D. B. (2008). Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. Am J Med Genet B Neuropsychiatr Genet, 147B(5), 667–668. https://doi.org/10.1002/ajmg.b.30658
Need, Anna C., Deborah K. Attix, Jill M. McEvoy, Elizabeth T. Cirulli, Kristen N. Linney, Ana Patricia Wagoner, Curtis E. Gumbs, et al. “Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.” Am J Med Genet B Neuropsychiatr Genet 147B, no. 5 (July 5, 2008): 667–68. https://doi.org/10.1002/ajmg.b.30658.
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, et al. Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):667–8.
Need, Anna C., et al. “Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.” Am J Med Genet B Neuropsychiatr Genet, vol. 147B, no. 5, July 2008, pp. 667–68. Pubmed, doi:10.1002/ajmg.b.30658.
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller H-J, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB. Failure to replicate effect of Kibra on human memory in two large cohorts of European origin. Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):667–668.
Published In
Am J Med Genet B Neuropsychiatr Genet
DOI
EISSN
1552-485X
Publication Date
July 5, 2008
Volume
147B
Issue
5
Start / End Page
667 / 668
Location
United States
Related Subject Headings
- White People
- Reproducibility of Results
- Proteins
- Polymorphism, Single Nucleotide
- Phosphoproteins
- Memory
- Intracellular Signaling Peptides and Proteins
- Humans
- Europe
- Cohort Studies