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Sagittal spinopelvic parameters in children with achondroplasia: identification of 2 distinct groups.

Publication ,  Journal Article
Karikari, IO; Mehta, AI; Solakoglu, C; Bagley, CA; Ain, MC; Gottfried, ON
Published in: J Neurosurg Spine
July 2012

OBJECT: Spinopelvic parameters in children with achondroplasia have not been described. Because they observed a unique sagittal spinopelvic phenotype in some achondroplastic children with very horizontal sacrums, the authors sought to quantify the spinopelvic parameters in a pediatric patient population. METHODS: A retrospective review was performed to identify all children (age range 1 month-10 years) with a diagnosis of achondroplasia between 2004 and 2009. Clinical and radiographic data were analyzed for age, sex, lumbar lordosis (LL), thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), sacral slope (SS), pelvic tilt (PT), and pelvic incidence (PI). Differences among these variables were analyzed using a 2-tailed, unpaired Student t-test. RESULTS: Forty children, 23 males and 17 females, with achondroplasia were identified during the study period. The mean age was 2.6 years. Two groups of patients were identified based on PT (that is, negative or positive tilt and horizontal or not horizontal sacrum). A negative PT was identified in all children with an extremely horizontal sacrum. Seventeen children had a negative PT (mean -16.6°), and the mean parameters in this group were 65.4° for LL, 31.7° for TLK, 18.5° for TK, 43.3° for SS, and 26.4° for PI. Twenty-three children had a positive PT (mean 17.9°), and the mean parameters in this group were 53.4° for LL, 41.5° for TLK, 9.6° for TK, 30.8° for SS, and 43.8° for PI. A statistically significant difference was observed for LL (p = 0.01), TLK (p = 0.05), SS (p = 0.006), PT (p = 0.006), and PI (0.0002). CONCLUSIONS: Spinopelvic parameters in achondroplasia are potentially dichotomous. The future implications of this observation are not known and will need to be explored in future long-term studies that follow pediatric patients with achondroplasia through adulthood.

Duke Scholars

Published In

J Neurosurg Spine

DOI

EISSN

1547-5646

Publication Date

July 2012

Volume

17

Issue

1

Start / End Page

57 / 60

Location

United States

Related Subject Headings

  • Thoracic Vertebrae
  • Spine
  • Sacrum
  • Retrospective Studies
  • Radiography
  • Postural Balance
  • Pelvic Bones
  • Orthopedics
  • Male
  • Lumbar Vertebrae
 

Citation

APA
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Karikari, I. O., Mehta, A. I., Solakoglu, C., Bagley, C. A., Ain, M. C., & Gottfried, O. N. (2012). Sagittal spinopelvic parameters in children with achondroplasia: identification of 2 distinct groups. J Neurosurg Spine, 17(1), 57–60. https://doi.org/10.3171/2012.3.SPINE11735
Karikari, Isaac O., Ankit I. Mehta, Can Solakoglu, Carlos A. Bagley, Michael C. Ain, and Oren N. Gottfried. “Sagittal spinopelvic parameters in children with achondroplasia: identification of 2 distinct groups.J Neurosurg Spine 17, no. 1 (July 2012): 57–60. https://doi.org/10.3171/2012.3.SPINE11735.
Karikari IO, Mehta AI, Solakoglu C, Bagley CA, Ain MC, Gottfried ON. Sagittal spinopelvic parameters in children with achondroplasia: identification of 2 distinct groups. J Neurosurg Spine. 2012 Jul;17(1):57–60.
Karikari, Isaac O., et al. “Sagittal spinopelvic parameters in children with achondroplasia: identification of 2 distinct groups.J Neurosurg Spine, vol. 17, no. 1, July 2012, pp. 57–60. Pubmed, doi:10.3171/2012.3.SPINE11735.
Karikari IO, Mehta AI, Solakoglu C, Bagley CA, Ain MC, Gottfried ON. Sagittal spinopelvic parameters in children with achondroplasia: identification of 2 distinct groups. J Neurosurg Spine. 2012 Jul;17(1):57–60.

Published In

J Neurosurg Spine

DOI

EISSN

1547-5646

Publication Date

July 2012

Volume

17

Issue

1

Start / End Page

57 / 60

Location

United States

Related Subject Headings

  • Thoracic Vertebrae
  • Spine
  • Sacrum
  • Retrospective Studies
  • Radiography
  • Postural Balance
  • Pelvic Bones
  • Orthopedics
  • Male
  • Lumbar Vertebrae