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The impact of lesion laterality on neuropsychological change following posterior pallidotomy: A review of current findings

Publication ,  Journal Article
Green, J; Barnhart, H
Published in: Brain and Cognition
2000

This paper reviews seven studies evaluating the impact of lesion laterality on the neuropsychological sequelae of posterior pallidotomy for treatment of Parkinson's disease. Left lesions of the internal globus pallidus (GPi) were associated with subtle deficits on measures sensitive to frontal lobe function. The findings of a randomized clinical trial including a patient control group indicated that many of these deficits were transient, resolving by 6 months following surgery. Right GPi lesions were not consistently associated with neuropsychological deficit, except in one study that included a significant proportion of demented patients. It is hypothesized that when neuropsychological decline is present following surgery, this reflects impingement of posterior GPi lesions into proximal regions such as anterior GPi or the external pallidum that participate in cognitive basal ganglia-thalamocortical circuits. The findings from neuroimaging will be important for elucidating the relationship between lesion locus and neuropsychological sequelae. (C) 2000 Academic Press.

Duke Scholars

Published In

Brain and Cognition

DOI

Publication Date

2000

Volume

42

Issue

3

Start / End Page

379 / 398

Related Subject Headings

  • Experimental Psychology
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Green, J., & Barnhart, H. (2000). The impact of lesion laterality on neuropsychological change following posterior pallidotomy: A review of current findings. Brain and Cognition, 42(3), 379–398. https://doi.org/10.1006/brcg.1999.1111
Green, J., and H. Barnhart. “The impact of lesion laterality on neuropsychological change following posterior pallidotomy: A review of current findings.” Brain and Cognition 42, no. 3 (2000): 379–98. https://doi.org/10.1006/brcg.1999.1111.
Green, J., and H. Barnhart. “The impact of lesion laterality on neuropsychological change following posterior pallidotomy: A review of current findings.” Brain and Cognition, vol. 42, no. 3, 2000, pp. 379–98. Scival, doi:10.1006/brcg.1999.1111.

Published In

Brain and Cognition

DOI

Publication Date

2000

Volume

42

Issue

3

Start / End Page

379 / 398

Related Subject Headings

  • Experimental Psychology
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences