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Multisite interstitial stimulation for cardiac micro-impedance measurements.

Publication ,  Journal Article
Pollard, AE; Barr, RC
Published in: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
January 2006

On theoretical grounds, interstitial current injected and removed using electrodes in close proximity does not cross the membrane, while equilibration of intracellular and interstitial potentials occurs distant from electrodes widely separated. Multisite interstitial stimulation should therefore give rise to interstitial potential differences recorded centrally that depend on intracellular and interstitial micro-impedances, allowing independent measurement. We tested the feasibility of completing such measurements using simulations of multisite stimulation with fine and wide spacing in models that included Luo-Rudy dynamic (LRd) membrane equations. Using two-dimensional models, test data (delta phi o) were generated with isotropic interstitial and intracellular micro-impedances prescribed for one set of simulations, and with anisotropic micro-impedances including unequal ratios (intracellular/interstitial) along and across fibers prescribed for another set of simulations. Micro-impedance measurements were then obtained by making statistical comparisons between delta phi o values and interstitial potential differences from passive bidomain simulations (Delta phi o) in which a wide range of possible micro-impedances were considered. Our findings suggest development of microfabricated devices to implement the multisite stimulation procedure would facilitate routine measurement as a component of cardiac electrophysiologic study.

Duke Scholars

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

DOI

ISSN

1557-170X

Publication Date

January 2006

Volume

2006

Start / End Page

1572 / 1575

Related Subject Headings

  • Plethysmography, Impedance
  • Myocytes, Cardiac
  • Models, Cardiovascular
  • Humans
  • Heart Conduction System
  • Electric Stimulation
  • Electric Impedance
  • Computer Simulation
  • Cardiac Pacing, Artificial
  • Animals
 

Citation

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ICMJE
MLA
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Pollard, A. E., & Barr, R. C. (2006). Multisite interstitial stimulation for cardiac micro-impedance measurements. Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006, 1572–1575. https://doi.org/10.1109/iembs.2006.260244
Pollard, Andrew E., and Roger C. Barr. “Multisite interstitial stimulation for cardiac micro-impedance measurements.Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2006 (January 2006): 1572–75. https://doi.org/10.1109/iembs.2006.260244.
Pollard AE, Barr RC. Multisite interstitial stimulation for cardiac micro-impedance measurements. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2006 Jan;2006:1572–5.
Pollard, Andrew E., and Roger C. Barr. “Multisite interstitial stimulation for cardiac micro-impedance measurements.Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2006, Jan. 2006, pp. 1572–75. Epmc, doi:10.1109/iembs.2006.260244.
Pollard AE, Barr RC. Multisite interstitial stimulation for cardiac micro-impedance measurements. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2006 Jan;2006:1572–1575.

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

DOI

ISSN

1557-170X

Publication Date

January 2006

Volume

2006

Start / End Page

1572 / 1575

Related Subject Headings

  • Plethysmography, Impedance
  • Myocytes, Cardiac
  • Models, Cardiovascular
  • Humans
  • Heart Conduction System
  • Electric Stimulation
  • Electric Impedance
  • Computer Simulation
  • Cardiac Pacing, Artificial
  • Animals