Factor IXa as a target for pharmacologic inhibition in acute coronary syndrome.
Anticoagulant therapy, combined with platelet-directed inhibitors, represents a standard-of-care in the management of patients with acute coronary syndrome, particularly those who require percutaneous coronary interventions. While a vast clinical experience, coupled with large clinical trials have collectively provided guidance, an optimal anticoagulant drug and applied strategy, defined as one that reduces thrombotic and hemorrhagic events consistently, with minimal off-target effects and active control of systemic anticoagulation according to patient and clinical-setting specific need, remains at large. An advancing knowledge of coagulation, hemostasis, and thrombosis suggests that factor IXa, a protease that governs thrombin generation in common thrombotic disorders may represent a prime target for pharmacologic inhibition.
Duke Scholars
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Related Subject Headings
- Thrombosis
- Protein Binding
- Humans
- Hemophilia B
- Factor IXa
- Cardiovascular System & Hematology
- Blood Platelets
- Binding Sites
- Aptamers, Nucleotide
- Antibodies, Monoclonal
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Thrombosis
- Protein Binding
- Humans
- Hemophilia B
- Factor IXa
- Cardiovascular System & Hematology
- Blood Platelets
- Binding Sites
- Aptamers, Nucleotide
- Antibodies, Monoclonal