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Beyond thrombosis: the versatile platelet in critical illness.

Publication ,  Journal Article
Katz, JN; Kolappa, KP; Becker, RC
Published in: Chest
March 2011

Sepsis, acute lung injury, and ARDS contribute substantially to the expanding burden of critical illness within our ICUs. Each of these processes is characterized by a myriad of injurious events, including apoptosis, microvascular dysfunction, abnormal coagulation, and dysregulated host immunity. Only recently have platelets--long considered merely effectors of thrombosis--been implicated in inflammatory conditions and the pathobiology of these disease processes. A growing body of evidence suggests a prominent role for maladaptive platelet activation and aggregation during sepsis and ARDS and has begun to underscore the pluripotential influence of platelets on outcomes in critical illness. Not only do platelets enhance vascular injury through thrombotic mechanisms but also appear to help orchestrate pathologic immune responses and are pivotal players in facilitating leukocyte recruitment to vulnerable tissue. These events contribute to the organ damage and poor patient outcomes that still plague the care of these high-risk individuals. An understanding of the role of platelets in critical illness also highlights the potential for both the development of risk stratification schema and the use of novel, targeted therapies that might alter the natural history of sepsis, acute lung injury, and ARDS. Future studies of adenosine, platelet polyphosphates, and the platelet transcriptome/proteome also should add considerably to our ability to unravel the mysteries of the versatile platelet.

Duke Scholars

Published In

Chest

DOI

EISSN

1931-3543

ISSN

0012-3692

Publication Date

March 2011

Volume

139

Issue

3

Start / End Page

658 / 668

Related Subject Headings

  • Thrombosis
  • Thrombocytopenia
  • Sepsis
  • Respiratory System
  • Respiratory Distress Syndrome
  • Immune System
  • Humans
  • Critical Illness
  • Blood Platelets
  • Acute Lung Injury
 

Citation

APA
Chicago
ICMJE
MLA
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Katz, J. N., Kolappa, K. P., & Becker, R. C. (2011). Beyond thrombosis: the versatile platelet in critical illness. Chest, 139(3), 658–668. https://doi.org/10.1378/chest.10-1971
Katz, Jason N., Kamalkumar P. Kolappa, and Richard C. Becker. “Beyond thrombosis: the versatile platelet in critical illness.Chest 139, no. 3 (March 2011): 658–68. https://doi.org/10.1378/chest.10-1971.
Katz JN, Kolappa KP, Becker RC. Beyond thrombosis: the versatile platelet in critical illness. Chest. 2011 Mar;139(3):658–68.
Katz, Jason N., et al. “Beyond thrombosis: the versatile platelet in critical illness.Chest, vol. 139, no. 3, Mar. 2011, pp. 658–68. Epmc, doi:10.1378/chest.10-1971.
Katz JN, Kolappa KP, Becker RC. Beyond thrombosis: the versatile platelet in critical illness. Chest. 2011 Mar;139(3):658–668.

Published In

Chest

DOI

EISSN

1931-3543

ISSN

0012-3692

Publication Date

March 2011

Volume

139

Issue

3

Start / End Page

658 / 668

Related Subject Headings

  • Thrombosis
  • Thrombocytopenia
  • Sepsis
  • Respiratory System
  • Respiratory Distress Syndrome
  • Immune System
  • Humans
  • Critical Illness
  • Blood Platelets
  • Acute Lung Injury