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Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients.

Publication ,  Journal Article
Dauerman, HL; Bhatt, DL; Gretler, DD; French, PA; Smyth, SS; Becker, RC
Published in: American heart journal
April 2010

Although patients aged > or =75 years represent nearly 40% of all those hospitalized with acute coronary syndromes, their enrollment in trials of therapeutic interventions has been relatively modest. Thus, scarce information exists to guide clinicians in decision-making and assessing projections of safety and efficacy for antiplatelet agents. The pathobiology of aging, including age-related changes in vascular repair and integrity, applies to patient management and offers a platform for investigation. Because older patients receive excess dosing of antithrombotic agents much more often than their younger counterparts do, initial steps toward optimized care include attention to indications, dosing, and duration of treatment. This review, representing a summary of information presented at the Fourth Annual Platelet Colloquium held in Washington, DC, in January 2009 and supplemented with recent clinical trial results, underscores an increasingly narrow safety index for antiplatelet agents in the elderly and the all-important balance of safety and efficacy--a dynamic continuum that remains paramount in quality of care. Considerations for future trial designs, registries, and analyses of existing data are highlighted to better guide clinicians toward the optimal management of this rapidly growing, high-risk group.

Duke Scholars

Published In

American heart journal

DOI

EISSN

1097-6744

ISSN

0002-8703

Publication Date

April 2010

Volume

159

Issue

4

Start / End Page

508 / 517.e1

Related Subject Headings

  • Platelet Aggregation Inhibitors
  • Humans
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • Aged
  • Age Factors
  • Acute Coronary Syndrome
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dauerman, H. L., Bhatt, D. L., Gretler, D. D., French, P. A., Smyth, S. S., & Becker, R. C. (2010). Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients. American Heart Journal, 159(4), 508-517.e1. https://doi.org/10.1016/j.ahj.2010.01.010
Dauerman, Harold L., Deepak L. Bhatt, Daniel D. Gretler, Patricia A. French, Susan S. Smyth, and Richard C. Becker. “Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients.American Heart Journal 159, no. 4 (April 2010): 508-517.e1. https://doi.org/10.1016/j.ahj.2010.01.010.
Dauerman HL, Bhatt DL, Gretler DD, French PA, Smyth SS, Becker RC. Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients. American heart journal. 2010 Apr;159(4):508-517.e1.
Dauerman, Harold L., et al. “Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients.American Heart Journal, vol. 159, no. 4, Apr. 2010, pp. 508-517.e1. Epmc, doi:10.1016/j.ahj.2010.01.010.
Dauerman HL, Bhatt DL, Gretler DD, French PA, Smyth SS, Becker RC. Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients. American heart journal. 2010 Apr;159(4):508-517.e1.
Journal cover image

Published In

American heart journal

DOI

EISSN

1097-6744

ISSN

0002-8703

Publication Date

April 2010

Volume

159

Issue

4

Start / End Page

508 / 517.e1

Related Subject Headings

  • Platelet Aggregation Inhibitors
  • Humans
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • Aged
  • Age Factors
  • Acute Coronary Syndrome
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology