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Cardiac rupture after myocardial infarction: new insights from murine models.

Publication ,  Journal Article
Sane, DC; Mozingo, WS; Becker, RC
Published in: Cardiology in review
November 2009

Cardiac rupture after a myocardial infarction is an uncommon event with devastating consequences. Although the clinical features of rupture have been described, the genetic and molecular influences on this outcome in patients are less certain. In mice, at least 17 genetic models have been developed that enhance or suppress the likelihood of rupture postmyocardial infarction. The purpose of this review is to describe these recent advances, recognizing that nearly all of the information has been obtained from mouse models of free wall rupture. Although it is probable that the same genetic determinants apply to septal and papillary muscle rupture, the possibility remains that there are unique modulators of risk for rupture at differing anatomic sites within the heart. It is likely that the candidate genes also influence rupture in humans, although this conclusion must be confirmed. The mouse models will be helpful to direct future proteomic and genomic studies in patients and may already suggest certain fundamental pathways. For example, the essential role of collagen production and stabilization postmyocardial infarction may direct therapies to enhance collagen cross-linking and limit its degradation as a strategy to reduce rates of rupture and enhance myocardial healing.

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Published In

Cardiology in review

DOI

EISSN

1538-4683

ISSN

1061-5377

Publication Date

November 2009

Volume

17

Issue

6

Start / End Page

293 / 299

Related Subject Headings

  • Proteomics
  • Models, Genetic
  • Models, Animal
  • Mice
  • Humans
  • Heart Rupture, Post-Infarction
  • Collagen
  • Cardiovascular System & Hematology
  • Animals
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Sane, D. C., Mozingo, W. S., & Becker, R. C. (2009). Cardiac rupture after myocardial infarction: new insights from murine models. Cardiology in Review, 17(6), 293–299. https://doi.org/10.1097/crd.0b013e3181bf4ab4
Sane, David C., Willis Scott Mozingo, and Richard C. Becker. “Cardiac rupture after myocardial infarction: new insights from murine models.Cardiology in Review 17, no. 6 (November 2009): 293–99. https://doi.org/10.1097/crd.0b013e3181bf4ab4.
Sane DC, Mozingo WS, Becker RC. Cardiac rupture after myocardial infarction: new insights from murine models. Cardiology in review. 2009 Nov;17(6):293–9.
Sane, David C., et al. “Cardiac rupture after myocardial infarction: new insights from murine models.Cardiology in Review, vol. 17, no. 6, Nov. 2009, pp. 293–99. Epmc, doi:10.1097/crd.0b013e3181bf4ab4.
Sane DC, Mozingo WS, Becker RC. Cardiac rupture after myocardial infarction: new insights from murine models. Cardiology in review. 2009 Nov;17(6):293–299.

Published In

Cardiology in review

DOI

EISSN

1538-4683

ISSN

1061-5377

Publication Date

November 2009

Volume

17

Issue

6

Start / End Page

293 / 299

Related Subject Headings

  • Proteomics
  • Models, Genetic
  • Models, Animal
  • Mice
  • Humans
  • Heart Rupture, Post-Infarction
  • Collagen
  • Cardiovascular System & Hematology
  • Animals
  • 3201 Cardiovascular medicine and haematology