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Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs.

Publication ,  Journal Article
Chan, MY; Weitz, JI; Merhi, Y; Harrington, RA; Becker, RC
Published in: Journal of thrombosis and thrombolysis
October 2009

Recent reports of catheter thrombosis among patients undergoing percutaneous coronary intervention (PCI) have had a significant impact on the development of new antithrombotic therapies. The overall incidence of this complication is unknown, mainly because of underreporting in contemporary clinical trials of coronary intervention. The etiology and pathophysiology of catheter thrombosis is also poorly understood. Introduction of a catheter or guidewire may not provoke the intense thrombotic response that follows angioplasty or stenting, but factors such as catheter materials and device size, equipment surface properties, flow conditions, procedural time and complexity, as well as the antiplatelet and anticoagulant drugs administered during the procedure influence the likelihood, rate and clinical impact of thrombosis. The crucial role of cellular interactions involving tissue-factor bearing cells and platelets in the process of thrombosis also needs to be critically explored when considering blood contact with an exogenous material. Focusing on the inherently prothrombotic environment of percutaneous coronary intervention, we review the physiologic underpinnings of catheter and guidewire thrombosis, and explore the effect of antithrombotic drugs at the interface between blood and material surfaces. We also propose a clinical classification for the diagnosis and investigation of catheter thrombosis in clinical trials of anticoagulant therapy and PCI.

Duke Scholars

Published In

Journal of thrombosis and thrombolysis

DOI

EISSN

1573-742X

ISSN

0929-5305

Publication Date

October 2009

Volume

28

Issue

3

Start / End Page

366 / 380

Related Subject Headings

  • Humans
  • Hematologic Agents
  • Coronary Thrombosis
  • Catheterization
  • Cardiovascular System & Hematology
  • Angioplasty, Balloon, Coronary
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chan, M. Y., Weitz, J. I., Merhi, Y., Harrington, R. A., & Becker, R. C. (2009). Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs. Journal of Thrombosis and Thrombolysis, 28(3), 366–380. https://doi.org/10.1007/s11239-009-0375-6
Chan, Mark Y., Jeffrey I. Weitz, Yahye Merhi, Robert A. Harrington, and Richard C. Becker. “Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs.Journal of Thrombosis and Thrombolysis 28, no. 3 (October 2009): 366–80. https://doi.org/10.1007/s11239-009-0375-6.
Chan MY, Weitz JI, Merhi Y, Harrington RA, Becker RC. Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs. Journal of thrombosis and thrombolysis. 2009 Oct;28(3):366–80.
Chan, Mark Y., et al. “Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs.Journal of Thrombosis and Thrombolysis, vol. 28, no. 3, Oct. 2009, pp. 366–80. Epmc, doi:10.1007/s11239-009-0375-6.
Chan MY, Weitz JI, Merhi Y, Harrington RA, Becker RC. Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs. Journal of thrombosis and thrombolysis. 2009 Oct;28(3):366–380.
Journal cover image

Published In

Journal of thrombosis and thrombolysis

DOI

EISSN

1573-742X

ISSN

0929-5305

Publication Date

October 2009

Volume

28

Issue

3

Start / End Page

366 / 380

Related Subject Headings

  • Humans
  • Hematologic Agents
  • Coronary Thrombosis
  • Catheterization
  • Cardiovascular System & Hematology
  • Angioplasty, Balloon, Coronary
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences