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Biological and pharmacological aspects of perioperative hemorrhagic complications associated with oral platelet-directed antithrombotic agents. Focus on isolated coronary artery bypass grafting and oral irreversible P2Y(12) receptor antagonists.

Publication ,  Journal Article
Becker, RC
Published in: Thrombosis research
January 2009

Coronary arterial bypass grafting (CABG)-the most common heart surgery performed worldwide-is an effective procedure for treating patients with advanced, obstructive atherothrombotic coronary artery disease, prolonging survival in selected high-risk patients. However, CABG is also associated with hemorrhagic complications, which can impact outcome measures such as perioperative morbidity, mortality, length of hospital stay, and health care expenditures. Recent observations have expanded our understanding of the complex process of hemostasis, fostering a more informed view of CABG-associated bleeding complications. Additional research is warranted to determine whether new antithrombotic drug treatment options, such as reversible P2Y12 receptor antagonists among patients with acute coronary syndromes, will favorably impact these clinically relevant complications.

Duke Scholars

Published In

Thrombosis research

DOI

EISSN

1879-2472

ISSN

0049-3848

Publication Date

January 2009

Volume

123

Issue

3

Start / End Page

419 / 428

Related Subject Headings

  • Thiophenes
  • Receptors, Purinergic P2Y12
  • Purinergic P2 Receptor Antagonists
  • Postoperative Hemorrhage
  • Platelet Aggregation Inhibitors
  • Humans
  • Hemostasis, Surgical
  • Hemostasis
  • Coronary Artery Bypass
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Journal cover image

Published In

Thrombosis research

DOI

EISSN

1879-2472

ISSN

0049-3848

Publication Date

January 2009

Volume

123

Issue

3

Start / End Page

419 / 428

Related Subject Headings

  • Thiophenes
  • Receptors, Purinergic P2Y12
  • Purinergic P2 Receptor Antagonists
  • Postoperative Hemorrhage
  • Platelet Aggregation Inhibitors
  • Humans
  • Hemostasis, Surgical
  • Hemostasis
  • Coronary Artery Bypass
  • Cardiovascular System & Hematology