Skip to main content
Journal cover image

The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development.

Publication ,  Journal Article
Elsayed, E; Becker, RC
Published in: Journal of thrombosis and thrombolysis
February 2003

Atherosclerotic disease is recognized as a chronic inflammatory disorder with intermittent and widely variable phases of cellular proliferation and heightened thrombotic activity. The multi-tiered links between inflammation, atherogenesis and thrombogenesis provide a unique opportunity for research and development of pharmaceuticals which target one or more critical pathobiologic steps (Fig. 1). The purpose of the following review on heparin compounds is to comprehensively examine the multi-cellular, pleuripotential effects of a commonly used anticoagulant drug in the context of normal and disease-altered vascular responses and illustrate possible constructs for avenues of subsequent investigation in the field of atherothrombosis. The overview is divided into five integrated parts; antiinflammatory properties of the normal vessel wall, the relationship between glycosaminoglycans and inflammation, heparin-mediated effects on cellular inflammatory responses, association between molecular weight and antiinflammatory capabilities, and oral heparin compounds for achieving prolonged cell-based inhibition.

Duke Scholars

Published In

Journal of thrombosis and thrombolysis

DOI

EISSN

1573-742X

ISSN

0929-5305

Publication Date

February 2003

Volume

15

Issue

1

Start / End Page

11 / 18

Related Subject Headings

  • Inflammation Mediators
  • Inflammation
  • Humans
  • Heparin
  • Glycosaminoglycans
  • Endothelium, Vascular
  • Cardiovascular System & Hematology
  • Animals
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Elsayed, E., & Becker, R. C. (2003). The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development. Journal of Thrombosis and Thrombolysis, 15(1), 11–18. https://doi.org/10.1023/a:1026184100030
Elsayed, Essam, and Richard C. Becker. “The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development.Journal of Thrombosis and Thrombolysis 15, no. 1 (February 2003): 11–18. https://doi.org/10.1023/a:1026184100030.
Elsayed, Essam, and Richard C. Becker. “The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development.Journal of Thrombosis and Thrombolysis, vol. 15, no. 1, Feb. 2003, pp. 11–18. Epmc, doi:10.1023/a:1026184100030.
Journal cover image

Published In

Journal of thrombosis and thrombolysis

DOI

EISSN

1573-742X

ISSN

0929-5305

Publication Date

February 2003

Volume

15

Issue

1

Start / End Page

11 / 18

Related Subject Headings

  • Inflammation Mediators
  • Inflammation
  • Humans
  • Heparin
  • Glycosaminoglycans
  • Endothelium, Vascular
  • Cardiovascular System & Hematology
  • Animals
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology