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Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury.

Publication ,  Journal Article
Nester, CM; Benner, EJ; Latour, M; Nickeleit, V; Hamrick, H; Primack, W
Published in: Am J Kidney Dis
May 2009

Cryoglobulinemia is rarely reported in children, and kidney failure secondary to cryoglobulinemia is even more uncommon. We report the case of a 7-year-old boy with cryoglobulins and a systemic illness, including persistent fever, arthralgias, rash, hypocomplementemia, and acute kidney injury associated with nephritic urine sediment. An extensive workup showed no infectious, neoplastic, or rheumatological cause of his kidney injury. The kidney biopsy specimen showed membranoproliferative glomerulonephritis type 1 with electron microscopic evidence of rhomboid crystalloid inclusions. These inclusions have rarely been reported in adult patients with cryoglobulinemia. The patient underwent spontaneous remission, including full recovery of kidney function, and required no immune suppression. The patient's course is consistent with cryoglobulinemia-associated kidney injury, which supports the inclusion of essential cryoglobulinemia in the differential diagnosis of pediatric patients with hypocomplementemic glomerulonephritis.

Duke Scholars

Published In

Am J Kidney Dis

DOI

EISSN

1523-6838

Publication Date

May 2009

Volume

53

Issue

5

Start / End Page

866 / 870

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Microscopy, Electron
  • Male
  • Kidney Glomerulus
  • Humans
  • Glomerulonephritis, Membranoproliferative
  • Diagnosis, Differential
  • Cryoglobulinemia
  • Complement System Proteins
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
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Nester, C. M., Benner, E. J., Latour, M., Nickeleit, V., Hamrick, H., & Primack, W. (2009). Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury. Am J Kidney Dis, 53(5), 866–870. https://doi.org/10.1053/j.ajkd.2009.01.015
Nester, Carla M., Eric J. Benner, Mathieu Latour, Volker Nickeleit, Harvey Hamrick, and William Primack. “Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury.Am J Kidney Dis 53, no. 5 (May 2009): 866–70. https://doi.org/10.1053/j.ajkd.2009.01.015.
Nester CM, Benner EJ, Latour M, Nickeleit V, Hamrick H, Primack W. Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury. Am J Kidney Dis. 2009 May;53(5):866–70.
Nester, Carla M., et al. “Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury.Am J Kidney Dis, vol. 53, no. 5, May 2009, pp. 866–70. Pubmed, doi:10.1053/j.ajkd.2009.01.015.
Nester CM, Benner EJ, Latour M, Nickeleit V, Hamrick H, Primack W. Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury. Am J Kidney Dis. 2009 May;53(5):866–870.
Journal cover image

Published In

Am J Kidney Dis

DOI

EISSN

1523-6838

Publication Date

May 2009

Volume

53

Issue

5

Start / End Page

866 / 870

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Microscopy, Electron
  • Male
  • Kidney Glomerulus
  • Humans
  • Glomerulonephritis, Membranoproliferative
  • Diagnosis, Differential
  • Cryoglobulinemia
  • Complement System Proteins
  • Child