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Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases.

Publication ,  Journal Article
Nilsson, KR; Bennett, V
Published in: J Cardiovasc Pharmacol
August 2009

The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and force-transducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

Duke Scholars

Published In

J Cardiovasc Pharmacol

DOI

EISSN

1533-4023

Publication Date

August 2009

Volume

54

Issue

2

Start / End Page

106 / 115

Location

United States

Related Subject Headings

  • Myocytes, Cardiac
  • Membrane Microdomains
  • Ion Channels
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Ankyrins
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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ICMJE
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Nilsson, K. R., & Bennett, V. (2009). Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases. J Cardiovasc Pharmacol, 54(2), 106–115. https://doi.org/10.1097/FJC.0b013e3181b2b6ed
Nilsson, Kent R., and Vann Bennett. “Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases.J Cardiovasc Pharmacol 54, no. 2 (August 2009): 106–15. https://doi.org/10.1097/FJC.0b013e3181b2b6ed.
Nilsson, Kent R., and Vann Bennett. “Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases.J Cardiovasc Pharmacol, vol. 54, no. 2, Aug. 2009, pp. 106–15. Pubmed, doi:10.1097/FJC.0b013e3181b2b6ed.

Published In

J Cardiovasc Pharmacol

DOI

EISSN

1533-4023

Publication Date

August 2009

Volume

54

Issue

2

Start / End Page

106 / 115

Location

United States

Related Subject Headings

  • Myocytes, Cardiac
  • Membrane Microdomains
  • Ion Channels
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Ankyrins
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3201 Cardiovascular medicine and haematology