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Being there: cellular targeting of voltage-gated sodium channels in the heart.

Publication ,  Journal Article
Bennett, V; Healy, J
Published in: J Cell Biol
January 14, 2008

Voltage-gated sodium (Na(v)) channels in cardiomyocytes are localized in specialized membrane domains that optimize their functions in propagating action potentials across cell junctions and in stimulating voltage-gated calcium channels located in T tubules. Mutation of the ankyrin-binding site of Na(v)1.5, the principal Na(v) channel in the heart, was previously known to cause cardiac arrhythmia and the retention of Na(v)1.5 in an intracellular compartment in cardiomyocytes. Conclusive evidence is now provided that direct interaction between Na(v)1.5 and ankyrin-G is necessary for the expression of Na(v)1.5 at the cardiomyocyte cell surface.

Duke Scholars

Published In

J Cell Biol

DOI

EISSN

1540-8140

Publication Date

January 14, 2008

Volume

180

Issue

1

Start / End Page

13 / 15

Location

United States

Related Subject Headings

  • Sodium Channels
  • NAV1.5 Voltage-Gated Sodium Channel
  • Myocytes, Cardiac
  • Muscle Proteins
  • Models, Biological
  • Mice
  • Ion Channel Gating
  • Humans
  • Developmental Biology
  • Binding Sites
 

Citation

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Bennett, V., & Healy, J. (2008). Being there: cellular targeting of voltage-gated sodium channels in the heart. J Cell Biol, 180(1), 13–15. https://doi.org/10.1083/jcb.200712098
Bennett, Vann, and Jane Healy. “Being there: cellular targeting of voltage-gated sodium channels in the heart.J Cell Biol 180, no. 1 (January 14, 2008): 13–15. https://doi.org/10.1083/jcb.200712098.
Bennett V, Healy J. Being there: cellular targeting of voltage-gated sodium channels in the heart. J Cell Biol. 2008 Jan 14;180(1):13–5.
Bennett, Vann, and Jane Healy. “Being there: cellular targeting of voltage-gated sodium channels in the heart.J Cell Biol, vol. 180, no. 1, Jan. 2008, pp. 13–15. Pubmed, doi:10.1083/jcb.200712098.
Bennett V, Healy J. Being there: cellular targeting of voltage-gated sodium channels in the heart. J Cell Biol. 2008 Jan 14;180(1):13–15.

Published In

J Cell Biol

DOI

EISSN

1540-8140

Publication Date

January 14, 2008

Volume

180

Issue

1

Start / End Page

13 / 15

Location

United States

Related Subject Headings

  • Sodium Channels
  • NAV1.5 Voltage-Gated Sodium Channel
  • Myocytes, Cardiac
  • Muscle Proteins
  • Models, Biological
  • Mice
  • Ion Channel Gating
  • Humans
  • Developmental Biology
  • Binding Sites