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Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells.

Publication ,  Journal Article
Rodriguez, GC; Turbov, JM; Berchuck, A; Stack, MS; Hurteau, JA; Thaete, LG; Barry, CP
Published in: Am J Obstet Gynecol
March 2012

OBJECTIVE: There is growing evidence that progestins and nonsteroidal antiinflammatory drugs (NSAIDs) may prevent ovarian cancer. Because both induce apoptosis, we investigated the potential for synergistic impact of combined drug treatment on cell death. STUDY DESIGN: Using normal and malignant human ovarian epithelial cells and an NSAID-sensitive human colon cancer cell line, we evaluated the effects of progestins and NSAIDs alone and in combination on apoptosis. RESULTS: Both progestins and NSAIDs dose dependently inhibited cell growth (P < .0001). Doses of NSAIDs or progestins that independently reduced cell viability by less than 30% synergistically reduced cell viability by 70-95% when combined. Similarly, the NSAID/progestin combination conferred 4- to 18-fold (P < .05) increased apoptosis over either treatment alone. CONCLUSION: Our results suggest it may be possible to combine progestins and NSAIDs to achieve ovarian cancer prevention at lower doses of each than are required for single administration, thereby lessening the risk of side effects posed by these agents.

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Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

March 2012

Volume

206

Issue

3

Start / End Page

253.e1 / 253.e9

Location

United States

Related Subject Headings

  • Progestins
  • Ovary
  • Ovarian Neoplasms
  • Obstetrics & Reproductive Medicine
  • Humans
  • Female
  • Drug Synergism
  • Cell Survival
  • Cell Proliferation
  • Cell Line, Tumor
 

Citation

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Rodriguez, G. C., Turbov, J. M., Berchuck, A., Stack, M. S., Hurteau, J. A., Thaete, L. G., & Barry, C. P. (2012). Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells. Am J Obstet Gynecol, 206(3), 253.e1-253.e9. https://doi.org/10.1016/j.ajog.2011.11.012
Rodriguez, Gustavo C., Jane M. Turbov, Andrew Berchuck, M Sharon Stack, Jean A. Hurteau, Larry G. Thaete, and Catherine P. Barry. “Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells.Am J Obstet Gynecol 206, no. 3 (March 2012): 253.e1-253.e9. https://doi.org/10.1016/j.ajog.2011.11.012.
Rodriguez GC, Turbov JM, Berchuck A, Stack MS, Hurteau JA, Thaete LG, et al. Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells. Am J Obstet Gynecol. 2012 Mar;206(3):253.e1-253.e9.
Rodriguez, Gustavo C., et al. “Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells.Am J Obstet Gynecol, vol. 206, no. 3, Mar. 2012, pp. 253.e1-253.e9. Pubmed, doi:10.1016/j.ajog.2011.11.012.
Rodriguez GC, Turbov JM, Berchuck A, Stack MS, Hurteau JA, Thaete LG, Barry CP. Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells. Am J Obstet Gynecol. 2012 Mar;206(3):253.e1-253.e9.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

March 2012

Volume

206

Issue

3

Start / End Page

253.e1 / 253.e9

Location

United States

Related Subject Headings

  • Progestins
  • Ovary
  • Ovarian Neoplasms
  • Obstetrics & Reproductive Medicine
  • Humans
  • Female
  • Drug Synergism
  • Cell Survival
  • Cell Proliferation
  • Cell Line, Tumor