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Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase.

Publication ,  Journal Article
Bilbo, SD; Hotchkiss, AK; Chiavegatto, S; Nelson, RJ
Published in: Journal of neuroimmunology
July 2003

Nitric oxide (NO) is implicated in inflammation and hypothalamic-pituitary responses to immune stimuli; however, the specific role of NO from neurons during stress-induced immune responses remains unspecified. We measured antigen-specific delayed-type-hypersensitivity (DTH) responses in the skin of wild-type (WT) and neuronal nitric oxide synthase knockout (nNOS(-/-)) mice at baseline and after 2 h of restraint. Baseline corticosterone concentrations were higher in nNOS(-/-) than WT mice. However, stress-induced increases in corticosterone were dampened in nNOS(-/-) mice, and restraint suppressed DTH only in WT animals. Furthermore, WT mice lost more body mass after stress, and exhibited more anxiety-like behavior in the open field, than nNOS(-/-) mice. Neuronal NO appears to be involved in the neuroendocrine-immune response to stress, perhaps via glucocorticoid regulation.

Duke Scholars

Published In

Journal of neuroimmunology

DOI

EISSN

1872-8421

ISSN

0165-5728

Publication Date

July 2003

Volume

140

Issue

1-2

Start / End Page

41 / 48

Related Subject Headings

  • Stress, Physiological
  • Restraint, Physical
  • Nitric Oxide Synthase Type I
  • Nitric Oxide Synthase
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Motor Activity
  • Mice, Knockout
  • Mice, Inbred C57BL
 

Citation

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Bilbo, S. D., Hotchkiss, A. K., Chiavegatto, S., & Nelson, R. J. (2003). Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. Journal of Neuroimmunology, 140(1–2), 41–48. https://doi.org/10.1016/s0165-5728(03)00175-9
Bilbo, Staci D., Andrew K. Hotchkiss, Silvana Chiavegatto, and Randy J. Nelson. “Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase.Journal of Neuroimmunology 140, no. 1–2 (July 2003): 41–48. https://doi.org/10.1016/s0165-5728(03)00175-9.
Bilbo SD, Hotchkiss AK, Chiavegatto S, Nelson RJ. Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. Journal of neuroimmunology. 2003 Jul;140(1–2):41–8.
Bilbo, Staci D., et al. “Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase.Journal of Neuroimmunology, vol. 140, no. 1–2, July 2003, pp. 41–48. Epmc, doi:10.1016/s0165-5728(03)00175-9.
Bilbo SD, Hotchkiss AK, Chiavegatto S, Nelson RJ. Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. Journal of neuroimmunology. 2003 Jul;140(1–2):41–48.
Journal cover image

Published In

Journal of neuroimmunology

DOI

EISSN

1872-8421

ISSN

0165-5728

Publication Date

July 2003

Volume

140

Issue

1-2

Start / End Page

41 / 48

Related Subject Headings

  • Stress, Physiological
  • Restraint, Physical
  • Nitric Oxide Synthase Type I
  • Nitric Oxide Synthase
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Motor Activity
  • Mice, Knockout
  • Mice, Inbred C57BL