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Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.

Publication ,  Journal Article
Demark-Wahnefried, W; Case, LD; Blackwell, K; Marcom, PK; Kraus, W; Aziz, N; Snyder, DC; Giguere, JK; Shaw, E
Published in: Clin Breast Cancer
February 2008

PURPOSE: Patients with breast cancer on adjuvant chemotherapy can experience weight gain and concurrent losses in muscle mass. Exercise interventions can prevent these changes, but time and travel pose barriers to participation. The Survivor Training for Enhancing Total Health (STRENGTH) trial assessed the feasibility and impact of 2 home-based interventions. PATIENTS AND METHODS: Ninety premenopausal patients with breast cancer on adjuvant chemotherapy were randomized to a calcium-rich diet (CA) intervention (attention control) or to 2 experimental arms: a CA + exercise (EX) arm or a CA + EX and high fruit and vegetable, low-fat diet (FVLF) arm. Exercise arms included aerobic and strength-training exercises. Body composition, weight status, waist circumference, dietary intake, physical activity, quality of life, anxiety, depression, serum lipids, sex hormone binding globulin, insulin, proinsulin, C-reactive protein, interleukin-1B, and tumor-necrosis factor receptor-II were measured at baseline and at 6-month follow-up. RESULTS: Accrual targets were achieved and modest attrition was observed (8.8%). Self-reports suggest increased calcium intakes in all arms, and higher fruit and vegetable and lower fat intake in the CA + EX + FVLF arm; no differences in physical activity were observed. While measures of adiposity were generally lower in the CA + EX + FVLF arm, the only significant difference was in percentage of body fat (arms and legs); change in scores (mean +/- standard deviation) were +0.7% +/- 2.3% (CA); +1.2% +/- 2.7% (CA + EX); and +0.1% +/- 2% (CA + EX + FVLF; P = .047). Lean body mass was largely preserved, even in the control arm (net gain of 452 g +/- 2395 g). No differences were observed in other endpoints. CONCLUSION: Diet and exercise interventions can prevent weight gain and adverse body composition changes, but more research is needed to determine optimally effective interventions that can be implemented during active treatment and that promote adherence.

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Published In

Clin Breast Cancer

DOI

ISSN

1526-8209

Publication Date

February 2008

Volume

8

Issue

1

Start / End Page

70 / 79

Location

United States

Related Subject Headings

  • Weight Gain
  • Premenopause
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Female
  • Feasibility Studies
  • Exercise
  • Diet, Fat-Restricted
  • Diet
 

Citation

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Chicago
ICMJE
MLA
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Demark-Wahnefried, W., Case, L. D., Blackwell, K., Marcom, P. K., Kraus, W., Aziz, N., … Shaw, E. (2008). Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy. Clin Breast Cancer, 8(1), 70–79. https://doi.org/10.3816/CBC.2008.n.005
Demark-Wahnefried, Wendy, L Douglas Case, Kimberly Blackwell, P Kelly Marcom, William Kraus, Noreen Aziz, Denise Clutter Snyder, Jeffrey K. Giguere, and Edward Shaw. “Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.Clin Breast Cancer 8, no. 1 (February 2008): 70–79. https://doi.org/10.3816/CBC.2008.n.005.
Demark-Wahnefried W, Case LD, Blackwell K, Marcom PK, Kraus W, Aziz N, et al. Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy. Clin Breast Cancer. 2008 Feb;8(1):70–9.
Demark-Wahnefried, Wendy, et al. “Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.Clin Breast Cancer, vol. 8, no. 1, Feb. 2008, pp. 70–79. Pubmed, doi:10.3816/CBC.2008.n.005.
Demark-Wahnefried W, Case LD, Blackwell K, Marcom PK, Kraus W, Aziz N, Snyder DC, Giguere JK, Shaw E. Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy. Clin Breast Cancer. 2008 Feb;8(1):70–79.
Journal cover image

Published In

Clin Breast Cancer

DOI

ISSN

1526-8209

Publication Date

February 2008

Volume

8

Issue

1

Start / End Page

70 / 79

Location

United States

Related Subject Headings

  • Weight Gain
  • Premenopause
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Female
  • Feasibility Studies
  • Exercise
  • Diet, Fat-Restricted
  • Diet