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Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial.

Publication ,  Journal Article
Conklin, HM; Helton, S; Ashford, J; Mulhern, RK; Reddick, WE; Brown, R; Bonner, M; Jasper, BW; Wu, S; Xiong, X; Khan, RB
Published in: J Pediatr Psychol
March 2010

OBJECTIVE: To investigate the methylphenidate (MPH) response rate among childhood survivors of acute lymphoblastic leukemia (ALL) and brain tumors (BTs) and to identify predictors of positive MPH response. METHODS: Cancer survivors (N = 106; BT = 51 and ALL = 55) identified as having attention deficits and learning problems participated in a 3-week, double-blind, crossover trial consisting of placebo, low-dose MPH (0.3 mg/kg), and moderate-dose MPH (0.6 mg/kg). Weekly teacher and parent reports on the Conners' Rating Scales were gathered. RESULTS: Following moderate MPH dose, 45.28% of the sample was classified as responders. Findings revealed that more problems endorsed prior to the medication trial on parent and teacher ratings were predictive of positive medication response (p < .05). CONCLUSIONS: MPH significantly reduces attention problems in a subset of childhood cancer survivors. Parent and teacher ratings may assist in identifying children most likely to respond to MPH so prescribing may be optimally targeted.

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Published In

J Pediatr Psychol

DOI

EISSN

1465-735X

Publication Date

March 2010

Volume

35

Issue

2

Start / End Page

144 / 155

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tennessee
  • Survivors
  • Severity of Illness Index
  • Psychological Tests
  • Predictive Value of Tests
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Methylphenidate
  • Male
  • Learning Disabilities
 

Citation

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Conklin, H. M., Helton, S., Ashford, J., Mulhern, R. K., Reddick, W. E., Brown, R., … Khan, R. B. (2010). Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial. J Pediatr Psychol, 35(2), 144–155. https://doi.org/10.1093/jpepsy/jsp044
Conklin, Heather M., Susan Helton, Jason Ashford, Raymond K. Mulhern, Wilburn E. Reddick, Ronald Brown, Melanie Bonner, et al. “Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial.J Pediatr Psychol 35, no. 2 (March 2010): 144–55. https://doi.org/10.1093/jpepsy/jsp044.
Conklin HM, Helton S, Ashford J, Mulhern RK, Reddick WE, Brown R, et al. Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial. J Pediatr Psychol. 2010 Mar;35(2):144–55.
Conklin, Heather M., et al. “Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial.J Pediatr Psychol, vol. 35, no. 2, Mar. 2010, pp. 144–55. Pubmed, doi:10.1093/jpepsy/jsp044.
Conklin HM, Helton S, Ashford J, Mulhern RK, Reddick WE, Brown R, Bonner M, Jasper BW, Wu S, Xiong X, Khan RB. Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial. J Pediatr Psychol. 2010 Mar;35(2):144–155.
Journal cover image

Published In

J Pediatr Psychol

DOI

EISSN

1465-735X

Publication Date

March 2010

Volume

35

Issue

2

Start / End Page

144 / 155

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tennessee
  • Survivors
  • Severity of Illness Index
  • Psychological Tests
  • Predictive Value of Tests
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Methylphenidate
  • Male
  • Learning Disabilities