Imaging surrogate end points in heart failure trials.
Publication
, Journal Article
Bettari, L; Borges-Neto, S
Published in: Heart Fail Clin
October 2011
Despite the epidemiologic importance, large investments, and careful design, recent results of heart failure (HF) trials have been unable to demonstrate significant treatment improvements. This shortcoming has led to a reassessment of research methodology, particularly related to sample size and costs, for which end-point selection is a main issue. In comparing interventions in clinical trials, surrogate end points may be used to reduce the costs. To this end, ongoing research into the roles of imaging biomarkers as reliable surrogate end points may lead to better clinical trial design and more efficient development of new therapies for HF.
Duke Scholars
Published In
Heart Fail Clin
DOI
ISSN
1551-7136
Publication Date
October 2011
Volume
7
Issue
4
Start / End Page
509 / 518
Location
United States
Related Subject Headings
- Severity of Illness Index
- Humans
- Heart Failure
- Disease Progression
- Clinical Trials as Topic
- Cardiovascular System & Hematology
- Biomarkers
- 3201 Cardiovascular medicine and haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Bettari, L., & Borges-Neto, S. (2011). Imaging surrogate end points in heart failure trials. Heart Fail Clin, 7(4), 509–518. https://doi.org/10.1016/j.hfc.2011.06.008
Bettari, Luca, and Salvador Borges-Neto. “Imaging surrogate end points in heart failure trials.” Heart Fail Clin 7, no. 4 (October 2011): 509–18. https://doi.org/10.1016/j.hfc.2011.06.008.
Bettari L, Borges-Neto S. Imaging surrogate end points in heart failure trials. Heart Fail Clin. 2011 Oct;7(4):509–18.
Bettari, Luca, and Salvador Borges-Neto. “Imaging surrogate end points in heart failure trials.” Heart Fail Clin, vol. 7, no. 4, Oct. 2011, pp. 509–18. Pubmed, doi:10.1016/j.hfc.2011.06.008.
Bettari L, Borges-Neto S. Imaging surrogate end points in heart failure trials. Heart Fail Clin. 2011 Oct;7(4):509–518.
Published In
Heart Fail Clin
DOI
ISSN
1551-7136
Publication Date
October 2011
Volume
7
Issue
4
Start / End Page
509 / 518
Location
United States
Related Subject Headings
- Severity of Illness Index
- Humans
- Heart Failure
- Disease Progression
- Clinical Trials as Topic
- Cardiovascular System & Hematology
- Biomarkers
- 3201 Cardiovascular medicine and haematology