Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.
Publication
, Journal Article
Møller, T; Franch, T; Højrup, P; Keene, DR; Bächinger, HP; Brennan, RG; Valentin-Hansen, P
Published in: Mol Cell
January 2002
The bacterial Hfq protein modulates the stability or the translation of mRNAs and has recently been shown to interact with small regulatory RNAs in E. coli. Here we show that Hfq belongs to the large family of Sm and Sm-like proteins: it contains a conserved sequence motif, known as the Sm1 motif, forms a doughnut-shaped structure, and has RNA binding specificity very similar to the Sm proteins. Moreover, we provide evidence that Hfq strongly cooperates in intermolecular base pairing between the antisense regulator Spot 42 RNA and its target RNA. We speculate that Sm proteins in general cooperate in bimolecular RNA-RNA interaction and that protein-mediated complex formation permits small RNAs to interact with a broad range of target RNAs.
Duke Scholars
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Published In
Mol Cell
DOI
ISSN
1097-2765
Publication Date
January 2002
Volume
9
Issue
1
Start / End Page
23 / 30
Location
United States
Related Subject Headings
- snRNP Core Proteins
- Ribonucleoproteins, Small Nuclear
- RNA, Messenger
- RNA, Bacterial
- Protein Biosynthesis
- Protein Binding
- Molecular Sequence Data
- Integration Host Factors
- Humans
- Host Factor 1 Protein
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Møller, T., Franch, T., Højrup, P., Keene, D. R., Bächinger, H. P., Brennan, R. G., & Valentin-Hansen, P. (2002). Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. Mol Cell, 9(1), 23–30. https://doi.org/10.1016/s1097-2765(01)00436-1
Møller, Thorleif, Thomas Franch, Peter Højrup, Douglas R. Keene, Hans Peter Bächinger, Richard G. Brennan, and Poul Valentin-Hansen. “Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.” Mol Cell 9, no. 1 (January 2002): 23–30. https://doi.org/10.1016/s1097-2765(01)00436-1.
Møller T, Franch T, Højrup P, Keene DR, Bächinger HP, Brennan RG, et al. Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. Mol Cell. 2002 Jan;9(1):23–30.
Møller, Thorleif, et al. “Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.” Mol Cell, vol. 9, no. 1, Jan. 2002, pp. 23–30. Pubmed, doi:10.1016/s1097-2765(01)00436-1.
Møller T, Franch T, Højrup P, Keene DR, Bächinger HP, Brennan RG, Valentin-Hansen P. Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. Mol Cell. 2002 Jan;9(1):23–30.
Published In
Mol Cell
DOI
ISSN
1097-2765
Publication Date
January 2002
Volume
9
Issue
1
Start / End Page
23 / 30
Location
United States
Related Subject Headings
- snRNP Core Proteins
- Ribonucleoproteins, Small Nuclear
- RNA, Messenger
- RNA, Bacterial
- Protein Biosynthesis
- Protein Binding
- Molecular Sequence Data
- Integration Host Factors
- Humans
- Host Factor 1 Protein