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Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.

Publication ,  Journal Article
Nordsmark, M; Bentzen, SM; Rudat, V; Brizel, D; Lartigau, E; Stadler, P; Becker, A; Adam, M; Molls, M; Dunst, J; Terris, DJ; Overgaard, J
Published in: Radiother Oncol
October 2005

PURPOSE: To analyze the relationship between pre-treatment measurements of tumor oxygen tension (pO2) and survival in advanced head and neck cancer. PATIENTS AND METHODS: Eppendorf pO2 measurements in 397 patients from seven centers were analyzed using the fraction of pO2 values < or =2.5 mmHg (HP2.5), < or =5 mmHg (HP5) and median tumor pO2 (mmHg) as descriptors. All patients had intended curative radiation therapy alone or as pre- or post-operative radiotherapy or radio-chemotherapy according to the practice at each center. RESULTS: The degree of hypoxia varied between tumors with an overall median tumor pO2=9 mmHg (range 0-62 mmHg), a median HP2.5=19% (range 0-97%) and HP5=38%, (range 0-100%). By quadratic regression median tumor pO2 correlated with Hb (2P=0.026, n=357), while HP2.5 or HP5 did not. HP2.5 above the population median was the only parameter that associated with poor overall survival (Kaplan Meier analysis, P=0.006). In a multivariate Cox Proportional Hazards analysis, stratified according to institution HP2.5 was by far the most statistically significant factor in explaining the variability in survival. After adjusting for HP2.5, clinical stage, radiation dose and surgery hemoglobin concentration was not significant in the model. The prognostic model shows that the 5-year survival is almost constant for HP2.5 values in the range from 0 to 20%, whereas the 5-year survival approaches 0% in the most hypoxic tumors. CONCLUSION: This study provides evidence that tumor hypoxia is associated with a poor prognosis in patients with advanced head and neck cancer.

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Published In

Radiother Oncol

DOI

ISSN

0167-8140

Publication Date

October 2005

Volume

77

Issue

1

Start / End Page

18 / 24

Location

Ireland

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Regression Analysis
  • Prospective Studies
  • Prognosis
  • Predictive Value of Tests
  • Oxygen
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
 

Citation

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Nordsmark, M., Bentzen, S. M., Rudat, V., Brizel, D., Lartigau, E., Stadler, P., … Overgaard, J. (2005). Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol, 77(1), 18–24. https://doi.org/10.1016/j.radonc.2005.06.038
Nordsmark, Marianne, Søren M. Bentzen, Volker Rudat, David Brizel, Eric Lartigau, Peter Stadler, Axel Becker, et al. “Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.Radiother Oncol 77, no. 1 (October 2005): 18–24. https://doi.org/10.1016/j.radonc.2005.06.038.
Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol. 2005 Oct;77(1):18–24.
Nordsmark, Marianne, et al. “Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.Radiother Oncol, vol. 77, no. 1, Oct. 2005, pp. 18–24. Pubmed, doi:10.1016/j.radonc.2005.06.038.
Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, Becker A, Adam M, Molls M, Dunst J, Terris DJ, Overgaard J. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol. 2005 Oct;77(1):18–24.
Journal cover image

Published In

Radiother Oncol

DOI

ISSN

0167-8140

Publication Date

October 2005

Volume

77

Issue

1

Start / End Page

18 / 24

Location

Ireland

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Regression Analysis
  • Prospective Studies
  • Prognosis
  • Predictive Value of Tests
  • Oxygen
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male