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Effects of four thrombolytic regimens in elderly patients

Publication ,  Journal Article
Straznicky, I; White, HD; Granger, CB; Aylward, PE; Barbash, GI; Topol, EJ; Califf, RM
Published in: Cardiology Review
July 13, 1998

The relationship between outcome and age for patients with acute myocardial infarction who are given thrombolytic therapy was analyzed in a population of 41,021 infarction patients randomly assigned to one of four thrombolytic treatment regimens. Increasing age was associated with increasing rates of mortality and hemorrhagic complications, regardless of treatment regimen. Use of tissue plasminogen activator was associated with increasing rates of hemorrhagic stroke in the elderly. However, even after this adverse effect was taken into account, for patients aged less than 85 years therapy with accelerated tissue plasminogen activator was associated with the greatest reduction in the combined rate of death and disabling stroke.

Duke Scholars

Published In

Cardiology Review

ISSN

1092-6607

Publication Date

July 13, 1998

Volume

15

Issue

1

Start / End Page

22 / 28

Related Subject Headings

  • Cardiovascular System & Hematology
 

Citation

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Straznicky, I., White, H. D., Granger, C. B., Aylward, P. E., Barbash, G. I., Topol, E. J., & Califf, R. M. (1998). Effects of four thrombolytic regimens in elderly patients. Cardiology Review, 15(1), 22–28.
Straznicky, I., H. D. White, C. B. Granger, P. E. Aylward, G. I. Barbash, E. J. Topol, and R. M. Califf. “Effects of four thrombolytic regimens in elderly patients.” Cardiology Review 15, no. 1 (July 13, 1998): 22–28.
Straznicky I, White HD, Granger CB, Aylward PE, Barbash GI, Topol EJ, et al. Effects of four thrombolytic regimens in elderly patients. Cardiology Review. 1998 Jul 13;15(1):22–8.
Straznicky, I., et al. “Effects of four thrombolytic regimens in elderly patients.” Cardiology Review, vol. 15, no. 1, July 1998, pp. 22–28.
Straznicky I, White HD, Granger CB, Aylward PE, Barbash GI, Topol EJ, Califf RM. Effects of four thrombolytic regimens in elderly patients. Cardiology Review. 1998 Jul 13;15(1):22–28.

Published In

Cardiology Review

ISSN

1092-6607

Publication Date

July 13, 1998

Volume

15

Issue

1

Start / End Page

22 / 28

Related Subject Headings

  • Cardiovascular System & Hematology