Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.
Publication
, Journal Article
Cardones, ARG; Hall, RP
Published in: Immunol Allergy Clin North Am
May 2012
Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualitatively different immune response to gluten in the intestinal mucosa of patients with DH results in minimal clinical symptoms, allowing the continued ingestion of gluten and the eventual development of DH. Our model may provide a new way to understand the pathogenesis of other skin diseases associated with gastrointestinal inflammation such as pyoderma gangrenosum or erythema nodosum, or explain association of seronegative inflammatory arthritis with inflammatory bowel disease.
Duke Scholars
Published In
Immunol Allergy Clin North Am
DOI
EISSN
1557-8607
Publication Date
May 2012
Volume
32
Issue
2
Start / End Page
263 / vi
Location
United States
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Skin
- Models, Biological
- Interleukin-8
- Inflammation Mediators
- Immunoglobulin A
- Immunity, Mucosal
- Humans
- Diet, Gluten-Free
- Dermatitis Herpetiformis
Citation
APA
Chicago
ICMJE
MLA
NLM
Cardones, A. R. G., & Hall, R. P. (2012). Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. Immunol Allergy Clin North Am, 32(2), 263–vi. https://doi.org/10.1016/j.iac.2012.04.006
Cardones, Adela Rambi G., and Russell P. Hall. “Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.” Immunol Allergy Clin North Am 32, no. 2 (May 2012): 263–vi. https://doi.org/10.1016/j.iac.2012.04.006.
Cardones ARG, Hall RP. Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. Immunol Allergy Clin North Am. 2012 May;32(2):263–vi.
Cardones, Adela Rambi G., and Russell P. Hall. “Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.” Immunol Allergy Clin North Am, vol. 32, no. 2, May 2012, pp. 263–vi. Pubmed, doi:10.1016/j.iac.2012.04.006.
Cardones ARG, Hall RP. Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. Immunol Allergy Clin North Am. 2012 May;32(2):263–vi.
Published In
Immunol Allergy Clin North Am
DOI
EISSN
1557-8607
Publication Date
May 2012
Volume
32
Issue
2
Start / End Page
263 / vi
Location
United States
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Skin
- Models, Biological
- Interleukin-8
- Inflammation Mediators
- Immunoglobulin A
- Immunity, Mucosal
- Humans
- Diet, Gluten-Free
- Dermatitis Herpetiformis