Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.
Publication
, Journal Article
Cardones, ARG; Hall, RP
Published in: Dermatol Clin
July 2011
Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualitatively different immune response to gluten in the intestinal mucosa of patients with DH results in minimal clinical symptoms, allowing the continued ingestion of gluten and the eventual development of DH. Our model may provide a new way to understand the pathogenesis of other skin diseases associated with gastrointestinal inflammation such as pyoderma gangrenosum or erythema nodosum, or explain association of seronegative inflammatory arthritis with inflammatory bowel disease.
Duke Scholars
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Published In
Dermatol Clin
DOI
EISSN
1558-0520
Publication Date
July 2011
Volume
29
Issue
3
Start / End Page
469 / x
Location
United States
Related Subject Headings
- Skin
- Humans
- Gastroenteritis
- Dermatology & Venereal Diseases
- Dermatitis Herpetiformis
- Autoimmunity
- Autoantibodies
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Cardones, A. R. G., & Hall, R. P. (2011). Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. Dermatol Clin, 29(3), 469–x. https://doi.org/10.1016/j.det.2011.03.005
Cardones, Adela Rambi G., and Russell P. Hall. “Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.” Dermatol Clin 29, no. 3 (July 2011): 469–x. https://doi.org/10.1016/j.det.2011.03.005.
Cardones ARG, Hall RP. Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. Dermatol Clin. 2011 Jul;29(3):469–x.
Cardones, Adela Rambi G., and Russell P. Hall. “Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.” Dermatol Clin, vol. 29, no. 3, July 2011, pp. 469–x. Pubmed, doi:10.1016/j.det.2011.03.005.
Cardones ARG, Hall RP. Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. Dermatol Clin. 2011 Jul;29(3):469–x.
Published In
Dermatol Clin
DOI
EISSN
1558-0520
Publication Date
July 2011
Volume
29
Issue
3
Start / End Page
469 / x
Location
United States
Related Subject Headings
- Skin
- Humans
- Gastroenteritis
- Dermatology & Venereal Diseases
- Dermatitis Herpetiformis
- Autoimmunity
- Autoantibodies
- 3202 Clinical sciences
- 1103 Clinical Sciences