Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion.
Publication
, Journal Article
Cassidy, F; Weiner, RD; Cooper, TB; Carroll, BJ
Published in: Prog Neuropsychopharmacol Biol Psychiatry
August 1, 2009
Although the antidepressant mechanism of ECT is unknown, there are data to support noradrenergic involvement. Patients who had been recently successfully treated with ECT for major depression were studied in a randomized double-blind cross-over design comparing catecholamine depletion using alpha-methyl-para-tyrosine to a placebo procedure. Mean MADRS scores at baseline (4.2 SD 2.7) and following depletion (4.6 SD 1.1) were similar, despite a 57.7% decrease in serum homovanillic acid (HVA) and a 61.5% decrease in 3-methoxy-4-hydroxyenylethyleneglycol (MHPG). These data suggest that catecholamine availability may not be necessary for acutely maintaining an antidepressant response to ECT.
Duke Scholars
Published In
Prog Neuropsychopharmacol Biol Psychiatry
DOI
EISSN
1878-4216
Publication Date
August 1, 2009
Volume
33
Issue
5
Start / End Page
872 / 874
Location
England
Related Subject Headings
- Psychiatry
- Middle Aged
- Male
- Humans
- Female
- Electroconvulsive Therapy
- Double-Blind Method
- Depressive Disorder, Major
- Cross-Over Studies
- Cohort Studies
Citation
APA
Chicago
ICMJE
MLA
NLM
Cassidy, F., Weiner, R. D., Cooper, T. B., & Carroll, B. J. (2009). Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion. Prog Neuropsychopharmacol Biol Psychiatry, 33(5), 872–874. https://doi.org/10.1016/j.pnpbp.2009.04.005
Cassidy, Frederick, Richard D. Weiner, Thomas B. Cooper, and Bernard J. Carroll. “Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion.” Prog Neuropsychopharmacol Biol Psychiatry 33, no. 5 (August 1, 2009): 872–74. https://doi.org/10.1016/j.pnpbp.2009.04.005.
Cassidy F, Weiner RD, Cooper TB, Carroll BJ. Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 1;33(5):872–4.
Cassidy, Frederick, et al. “Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion.” Prog Neuropsychopharmacol Biol Psychiatry, vol. 33, no. 5, Aug. 2009, pp. 872–74. Pubmed, doi:10.1016/j.pnpbp.2009.04.005.
Cassidy F, Weiner RD, Cooper TB, Carroll BJ. Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 1;33(5):872–874.
Published In
Prog Neuropsychopharmacol Biol Psychiatry
DOI
EISSN
1878-4216
Publication Date
August 1, 2009
Volume
33
Issue
5
Start / End Page
872 / 874
Location
England
Related Subject Headings
- Psychiatry
- Middle Aged
- Male
- Humans
- Female
- Electroconvulsive Therapy
- Double-Blind Method
- Depressive Disorder, Major
- Cross-Over Studies
- Cohort Studies