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ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.

Publication ,  Journal Article
Alaynick, WA; Way, JM; Wilson, SA; Benson, WG; Pei, L; Downes, M; Yu, R; Jonker, JW; Holt, JA; Rajpal, DK; Li, H; Stuart, J; McPherson, R ...
Published in: Mol Endocrinol
February 2010

Energy production by oxidative metabolism in kidney, stomach, and heart, is primarily expended in establishing ion gradients to drive renal electrolyte homeostasis, gastric acid secretion, and cardiac muscle contraction, respectively. In addition to orchestrating transcriptional control of oxidative metabolism, the orphan nuclear receptor, estrogen-related receptor gamma (ERRgamma), coordinates expression of genes central to ion homeostasis in oxidative tissues. Renal, gastric, and cardiac tissues subjected to genomic analysis of expression in perinatal ERRgamma null mice revealed a characteristic dysregulation of genes involved in transport processes, exemplified by the voltage-gated potassium channel, Kcne2. Consistently, ERRgamma null animals die during the first 72 h of life with elevated serum potassium, reductions in key gastric acid production markers, and cardiac arrhythmia with prolonged QT intervals. In addition, we find altered expression of several genes associated with hypertension in ERRgamma null mice. These findings suggest a potential role for genetic polymorphisms at the ERRgamma locus and ERRgamma modulators in the etiology and treatment of renal, gastric, and cardiac dysfunction.

Duke Scholars

Published In

Mol Endocrinol

DOI

EISSN

1944-9917

Publication Date

February 2010

Volume

24

Issue

2

Start / End Page

299 / 309

Location

United States

Related Subject Headings

  • Stomach
  • Receptors, Estrogen
  • Potassium Channels, Voltage-Gated
  • Potassium
  • Polymorphism, Single Nucleotide
  • Organ Specificity
  • Oligonucleotide Array Sequence Analysis
  • Myocardium
  • Middle Aged
  • Mice
 

Citation

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Alaynick, W. A., Way, J. M., Wilson, S. A., Benson, W. G., Pei, L., Downes, M., … Billin, A. N. (2010). ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol, 24(2), 299–309. https://doi.org/10.1210/me.2009-0114
Alaynick, William A., James M. Way, Stephanie A. Wilson, William G. Benson, Liming Pei, Michael Downes, Ruth Yu, et al. “ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.Mol Endocrinol 24, no. 2 (February 2010): 299–309. https://doi.org/10.1210/me.2009-0114.
Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, et al. ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol. 2010 Feb;24(2):299–309.
Alaynick, William A., et al. “ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.Mol Endocrinol, vol. 24, no. 2, Feb. 2010, pp. 299–309. Pubmed, doi:10.1210/me.2009-0114.
Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang C-Y, McDonnell DP, Evans RM, Billin AN. ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol. 2010 Feb;24(2):299–309.

Published In

Mol Endocrinol

DOI

EISSN

1944-9917

Publication Date

February 2010

Volume

24

Issue

2

Start / End Page

299 / 309

Location

United States

Related Subject Headings

  • Stomach
  • Receptors, Estrogen
  • Potassium Channels, Voltage-Gated
  • Potassium
  • Polymorphism, Single Nucleotide
  • Organ Specificity
  • Oligonucleotide Array Sequence Analysis
  • Myocardium
  • Middle Aged
  • Mice