Androgen receptor-cofactor interactions as targets for new drug discovery.
Publication
, Journal Article
Chang, C-Y; McDonnell, DP
Published in: Trends Pharmacol Sci
May 2005
Cofactor recruitment is a crucial regulatory step in nuclear receptor signal transduction. Given the obligate nature of interactions between cofactors and these receptors for transcriptional activity, it is likely that drugs that target coactivator interaction surfaces will function as pure antagonists with particular utility in the treatment of estrogen- and androgen-dependent cancers. Recent crystallographic analysis of one of the major protein-protein interaction surfaces on the androgen receptor has raised expectations that it will be possible to develop small-molecule antagonists that block cofactor interactions.
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Published In
Trends Pharmacol Sci
DOI
ISSN
0165-6147
Publication Date
May 2005
Volume
26
Issue
5
Start / End Page
225 / 228
Location
England
Related Subject Headings
- Transcription Factors
- Receptors, Androgen
- Pharmacology & Pharmacy
- Ligands
- Drug Design
- Binding Sites
- 3214 Pharmacology and pharmaceutical sciences
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Chang, C.-Y., & McDonnell, D. P. (2005). Androgen receptor-cofactor interactions as targets for new drug discovery. Trends Pharmacol Sci, 26(5), 225–228. https://doi.org/10.1016/j.tips.2005.03.002
Chang, Ching-yi, and Donald P. McDonnell. “Androgen receptor-cofactor interactions as targets for new drug discovery.” Trends Pharmacol Sci 26, no. 5 (May 2005): 225–28. https://doi.org/10.1016/j.tips.2005.03.002.
Chang C-Y, McDonnell DP. Androgen receptor-cofactor interactions as targets for new drug discovery. Trends Pharmacol Sci. 2005 May;26(5):225–8.
Chang, Ching-yi, and Donald P. McDonnell. “Androgen receptor-cofactor interactions as targets for new drug discovery.” Trends Pharmacol Sci, vol. 26, no. 5, May 2005, pp. 225–28. Pubmed, doi:10.1016/j.tips.2005.03.002.
Chang C-Y, McDonnell DP. Androgen receptor-cofactor interactions as targets for new drug discovery. Trends Pharmacol Sci. 2005 May;26(5):225–228.
Published In
Trends Pharmacol Sci
DOI
ISSN
0165-6147
Publication Date
May 2005
Volume
26
Issue
5
Start / End Page
225 / 228
Location
England
Related Subject Headings
- Transcription Factors
- Receptors, Androgen
- Pharmacology & Pharmacy
- Ligands
- Drug Design
- Binding Sites
- 3214 Pharmacology and pharmaceutical sciences
- 11 Medical and Health Sciences
- 06 Biological Sciences