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Haploidentical transplantation for leukemia.

Publication ,  Journal Article
Kanda, J; Chao, NJ; Rizzieri, DA
Published in: Curr Oncol Rep
September 2010

Hematopoietic stem cell transplantation from human leukocyte antigen (HLA)-haploidentical family members offers a potential cure for patients in need of allogeneic immunotherapy who have no immediate access to an HLA-matched donor. The use of ex vivo T-cell-depleted stem cells combined with immuno-myeloablative conditioning has enabled durable donor engraftment with a low incidence of acute graft-versus-host disease despite the HLA disparity. Moreover, additional transplant techniques involving in vivo T-cell depletion and reduced-intensity conditioning have further minimized the risks. However, a major drawback is delayed immune reconstitution leading to infections and high relapse rates, prompting significant research efforts focused on improving recovery in the post-transplant period. Infusions with donor lymphocytes are common, though newer manipulations with a focus on donor natural killer cells hold great promise, as do other modified donor T-cell infusions. Success of these new procedures will make haploidentical transplants safer and more effective, further broadening its appeal.

Duke Scholars

Published In

Curr Oncol Rep

DOI

EISSN

1534-6269

Publication Date

September 2010

Volume

12

Issue

5

Start / End Page

292 / 301

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Oncology & Carcinogenesis
  • Leukemia
  • Humans
  • Histocompatibility
  • Hematopoietic Stem Cell Transplantation
  • HLA Antigens
  • Graft Survival
  • Clinical Trials as Topic
  • 3211 Oncology and carcinogenesis
 

Citation

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Kanda, J., Chao, N. J., & Rizzieri, D. A. (2010). Haploidentical transplantation for leukemia. Curr Oncol Rep, 12(5), 292–301. https://doi.org/10.1007/s11912-010-0113-4
Kanda, Junya, Nelson J. Chao, and David A. Rizzieri. “Haploidentical transplantation for leukemia.Curr Oncol Rep 12, no. 5 (September 2010): 292–301. https://doi.org/10.1007/s11912-010-0113-4.
Kanda J, Chao NJ, Rizzieri DA. Haploidentical transplantation for leukemia. Curr Oncol Rep. 2010 Sep;12(5):292–301.
Kanda, Junya, et al. “Haploidentical transplantation for leukemia.Curr Oncol Rep, vol. 12, no. 5, Sept. 2010, pp. 292–301. Pubmed, doi:10.1007/s11912-010-0113-4.
Kanda J, Chao NJ, Rizzieri DA. Haploidentical transplantation for leukemia. Curr Oncol Rep. 2010 Sep;12(5):292–301.
Journal cover image

Published In

Curr Oncol Rep

DOI

EISSN

1534-6269

Publication Date

September 2010

Volume

12

Issue

5

Start / End Page

292 / 301

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Oncology & Carcinogenesis
  • Leukemia
  • Humans
  • Histocompatibility
  • Hematopoietic Stem Cell Transplantation
  • HLA Antigens
  • Graft Survival
  • Clinical Trials as Topic
  • 3211 Oncology and carcinogenesis