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Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.

Publication ,  Journal Article
Kang, Y; Chen, BJ; Deoliveira, D; Mito, J; Chao, NJ
Published in: PLoS One
June 28, 2010

The interaction between stromal cell-derived factor-1 (SDF-1) with CXCR4 chemokine receptors plays an important role in hematopoiesis following hematopoietic stem cell transplantation. We examined the efficacy of post transplant administration of a specific CXCR4 antagonist (AMD3100) in improving animal survival and in enhancing donor hematopoietic cell engraftment using a congeneic mouse transplantation model. AMD3100 was administered subcutaneously at 5 mg/kg body weight 3 times a week beginning at day +2 post-transplant. Post-transplant administration of AMD3100 significantly improves animal survival. AMD3100 reduces pro-inflammatory cytokine/chemokine production. Furthermore, post transplant administration of AMD3100 selectively enhances donor cell engraftment and promotes recovery of all donor cell lineages (myeloid cells, T and B lymphocytes, erythrocytes and platelets). This enhancement results from a combined effect of increased marrow niche availability and greater cell division induced by AMD3100. Our studies shed new lights into the biological roles of SDF-1/CXCR4 interaction in hematopoietic stem cell engraftment following transplantation and in transplant-related mortality. Our results indicate that AMD3100 provides a novel approach for enhancing hematological recovery following transplantation, and will likely benefit patients undergoing transplantation.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

June 28, 2010

Volume

5

Issue

6

Start / End Page

e11316

Location

United States

Related Subject Headings

  • Receptors, CXCR4
  • Mice
  • Heterocyclic Compounds
  • Hematopoietic Stem Cells
  • Hematopoietic Stem Cell Transplantation
  • General Science & Technology
  • Cytokines
  • Cyclams
  • Benzylamines
  • Animals
 

Citation

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MLA
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Kang, Y., Chen, B. J., Deoliveira, D., Mito, J., & Chao, N. J. (2010). Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model. PLoS One, 5(6), e11316. https://doi.org/10.1371/journal.pone.0011316
Kang, Yubin, Benny J. Chen, Divino Deoliveira, Jeffrey Mito, and Nelson J. Chao. “Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.PLoS One 5, no. 6 (June 28, 2010): e11316. https://doi.org/10.1371/journal.pone.0011316.
Kang, Yubin, et al. “Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.PLoS One, vol. 5, no. 6, June 2010, p. e11316. Pubmed, doi:10.1371/journal.pone.0011316.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

June 28, 2010

Volume

5

Issue

6

Start / End Page

e11316

Location

United States

Related Subject Headings

  • Receptors, CXCR4
  • Mice
  • Heterocyclic Compounds
  • Hematopoietic Stem Cells
  • Hematopoietic Stem Cell Transplantation
  • General Science & Technology
  • Cytokines
  • Cyclams
  • Benzylamines
  • Animals