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Umbilical cord blood: biology and transplantation.

Publication ,  Journal Article
Doan, PL; Chao, NJ
Published in: Expert Rev Hematol
April 2009

Umbilical cord blood transplantation is becoming an acceptable alternative source of hematopoietic stem cells for patients with malignant diseases. Cord blood differs from bone marrow and peripheral blood progenitors in its immune tolerance and kinetics of engraftment. In this article, we will review the biology of cord blood stem cells and clinical studies of cord blood transplants in pediatric and adult populations. We will also discuss potential uses of cord blood stem cells in regenerative medicine and novel methods for ex vivo expansion of hematopoietic stem cells. As we learn more about cord blood transplants, there is the potential to overcome the limitations of cord blood transplants so that they can become more widely available.

Duke Scholars

Published In

Expert Rev Hematol

DOI

EISSN

1747-4094

Publication Date

April 2009

Volume

2

Issue

2

Start / End Page

197 / 208

Location

England

Related Subject Headings

  • Humans
  • Fetal Blood
  • Cord Blood Stem Cell Transplantation
  • Child
  • Adult
  • 3201 Cardiovascular medicine and haematology
  • 1199 Other Medical and Health Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Chicago
ICMJE
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Doan, P. L., & Chao, N. J. (2009). Umbilical cord blood: biology and transplantation. Expert Rev Hematol, 2(2), 197–208. https://doi.org/10.1586/ehm.09.9
Doan, Phuong L., and Nelson J. Chao. “Umbilical cord blood: biology and transplantation.Expert Rev Hematol 2, no. 2 (April 2009): 197–208. https://doi.org/10.1586/ehm.09.9.
Doan PL, Chao NJ. Umbilical cord blood: biology and transplantation. Expert Rev Hematol. 2009 Apr;2(2):197–208.
Doan, Phuong L., and Nelson J. Chao. “Umbilical cord blood: biology and transplantation.Expert Rev Hematol, vol. 2, no. 2, Apr. 2009, pp. 197–208. Pubmed, doi:10.1586/ehm.09.9.
Doan PL, Chao NJ. Umbilical cord blood: biology and transplantation. Expert Rev Hematol. 2009 Apr;2(2):197–208.

Published In

Expert Rev Hematol

DOI

EISSN

1747-4094

Publication Date

April 2009

Volume

2

Issue

2

Start / End Page

197 / 208

Location

England

Related Subject Headings

  • Humans
  • Fetal Blood
  • Cord Blood Stem Cell Transplantation
  • Child
  • Adult
  • 3201 Cardiovascular medicine and haematology
  • 1199 Other Medical and Health Sciences
  • 1102 Cardiorespiratory Medicine and Haematology