Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain.
Publication
, Journal Article
Xie, H; Belogortseva, NI; Wu, J; Lai, W-H; Chen, C-H
Published in: Antimicrob Agents Chemother
September 2006
Human immunodeficiency virus (HIV) transmission through saliva is extremely low. Several oral components, including secretory immunoglobulin A and secretory leukocyte protease inhibitor, are known as potential inhibitory agents of HIV oral transmission. Here we examined anti-HIV activity of oral bacterial components. We showed that recombinant protein HGP44 derived from Porphyromonas gingivalis, one of the primary infectious agents of periodontitis, was capable of inhibiting HIV type 1 (HIV-1) replication. HGP44 bound specifically to HIV-1 gp120 and blocked HIV-1 envelope-mediated membrane fusion. These findings suggest that HGP44 of P. gingivalis can inhibit HIV-1 infection by blocking HIV-1 entry.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
September 2006
Volume
50
Issue
9
Start / End Page
3070 / 3074
Location
United States
Related Subject Headings
- Virus Replication
- Protein Structure, Tertiary
- Porphyromonas gingivalis
- Peptide Fragments
- Microbiology
- Humans
- HIV-1
- HIV Infections
- HIV Envelope Protein gp120
- Gingipain Cysteine Endopeptidases
Citation
APA
Chicago
ICMJE
MLA
NLM
Xie, H., Belogortseva, N. I., Wu, J., Lai, W.-H., & Chen, C.-H. (2006). Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain. Antimicrob Agents Chemother, 50(9), 3070–3074. https://doi.org/10.1128/AAC.01578-05
Xie, Hua, Natalya I. Belogortseva, Jie Wu, Wei-Hong Lai, and Chin-ho Chen. “Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain.” Antimicrob Agents Chemother 50, no. 9 (September 2006): 3070–74. https://doi.org/10.1128/AAC.01578-05.
Xie H, Belogortseva NI, Wu J, Lai W-H, Chen C-H. Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain. Antimicrob Agents Chemother. 2006 Sep;50(9):3070–4.
Xie, Hua, et al. “Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain.” Antimicrob Agents Chemother, vol. 50, no. 9, Sept. 2006, pp. 3070–74. Pubmed, doi:10.1128/AAC.01578-05.
Xie H, Belogortseva NI, Wu J, Lai W-H, Chen C-H. Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain. Antimicrob Agents Chemother. 2006 Sep;50(9):3070–3074.
Published In
Antimicrob Agents Chemother
DOI
ISSN
0066-4804
Publication Date
September 2006
Volume
50
Issue
9
Start / End Page
3070 / 3074
Location
United States
Related Subject Headings
- Virus Replication
- Protein Structure, Tertiary
- Porphyromonas gingivalis
- Peptide Fragments
- Microbiology
- Humans
- HIV-1
- HIV Infections
- HIV Envelope Protein gp120
- Gingipain Cysteine Endopeptidases