Betulinic acid derivatives as HIV-1 antivirals.
Betulinic acid (BA) derivatives are low molecular weight organic compounds synthesized from a plant-derived natural product. Several BA derivatives are potent and highly selective inhibitors of HIV-1. Depending on the specific side-chain modification, these compounds function by inhibiting HIV fusion or, as recently demonstrated, by interfering with a specific step in HIV-1 maturation. BA derivatives have potential as novel HIV-1 therapies, and additional studies of their mechanisms of action are likely to further define the novel targets of these compounds and elucidate the basic biology of HIV-1 fusion and maturation. In this review, recent studies of the novel mechanisms of action of this interesting class of antiviral compounds are discussed.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Virus Replication
- Triterpenes
- Pentacyclic Triterpenes
- Immunology
- Humans
- HIV-1
- Betulinic Acid
- Anti-HIV Agents
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Virus Replication
- Triterpenes
- Pentacyclic Triterpenes
- Immunology
- Humans
- HIV-1
- Betulinic Acid
- Anti-HIV Agents
- 42 Health sciences
- 32 Biomedical and clinical sciences