Skip to main content
Journal cover image

Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41.

Publication ,  Journal Article
Huang, L; Zhang, L; Chen, CH
Published in: Curr Pharm Des
2003

HIV-1 entry is an attractive target for anti-HIV-1 therapy. However, there are no entry inhibitors approved for the clinical treatment of HIV-1 infection. This is likely to be changed in the near future since promising HIV-1 entry inhibitors, such as T20 and some chemokine receptor antagonists, are in the pipeline to join the repertoire of anti-HIV-1 therapeutics. This review will focus on what might be potential targets on the key components of the viral entry machinery, gp120 and gp41. These two molecules are the viral proteins responsible for HIV-1 entry. Binding to CD4 induces a series of structural changes in gp120 and allows it to interact with chemokine receptors. The receptor binding eventually triggers conformational changes in gp41, which result in the formation of a fusion active molecule to attack the cell membrane. The structural and functional motifs that operate this delicate fusion machinery could become the Achilles' heel of the virus.

Duke Scholars

Published In

Curr Pharm Des

DOI

ISSN

1381-6128

Publication Date

2003

Volume

9

Issue

18

Start / End Page

1453 / 1462

Location

United Arab Emirates

Related Subject Headings

  • Virus Replication
  • Medicinal & Biomolecular Chemistry
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp41
  • HIV Envelope Protein gp120
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huang, L., Zhang, L., & Chen, C. H. (2003). Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41. Curr Pharm Des, 9(18), 1453–1462. https://doi.org/10.2174/1381612033454720
Huang, Li, Linda Zhang, and Chin Ho Chen. “Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41.Curr Pharm Des 9, no. 18 (2003): 1453–62. https://doi.org/10.2174/1381612033454720.
Huang L, Zhang L, Chen CH. Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41. Curr Pharm Des. 2003;9(18):1453–62.
Huang, Li, et al. “Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41.Curr Pharm Des, vol. 9, no. 18, 2003, pp. 1453–62. Pubmed, doi:10.2174/1381612033454720.
Huang L, Zhang L, Chen CH. Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41. Curr Pharm Des. 2003;9(18):1453–1462.
Journal cover image

Published In

Curr Pharm Des

DOI

ISSN

1381-6128

Publication Date

2003

Volume

9

Issue

18

Start / End Page

1453 / 1462

Location

United Arab Emirates

Related Subject Headings

  • Virus Replication
  • Medicinal & Biomolecular Chemistry
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp41
  • HIV Envelope Protein gp120
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences