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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.

Publication ,  Journal Article
Lee, Y-C; Kuo, H-C; Chang, J-S; Chang, L-Y; Huang, L-M; Chen, M-R; Liang, C-D; Chi, H; Huang, F-Y; Lee, M-L; Huang, Y-C; Hwang, B; Chiu, N-C ...
Published in: Nat Genet
March 25, 2012

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

March 25, 2012

Volume

44

Issue

5

Start / End Page

522 / 525

Location

United States

Related Subject Headings

  • Taiwan
  • Polymorphism, Single Nucleotide
  • Mucocutaneous Lymph Node Syndrome
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Genetic Markers
  • Genetic Loci
  • Developmental Biology
  • Case-Control Studies
 

Citation

APA
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MLA
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Lee, Y.-C., Kuo, H.-C., Chang, J.-S., Chang, L.-Y., Huang, L.-M., Chen, M.-R., … Wu, J.-Y. (2012). Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet, 44(5), 522–525. https://doi.org/10.1038/ng.2227
Lee, Yi-Ching, Ho-Chang Kuo, Jeng-Sheng Chang, Luan-Yin Chang, Li-Min Huang, Ming-Ren Chen, Chi-Di Liang, et al. “Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.Nat Genet 44, no. 5 (March 25, 2012): 522–25. https://doi.org/10.1038/ng.2227.
Lee Y-C, Kuo H-C, Chang J-S, Chang L-Y, Huang L-M, Chen M-R, et al. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet. 2012 Mar 25;44(5):522–5.
Lee, Yi-Ching, et al. “Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.Nat Genet, vol. 44, no. 5, Mar. 2012, pp. 522–25. Pubmed, doi:10.1038/ng.2227.
Lee Y-C, Kuo H-C, Chang J-S, Chang L-Y, Huang L-M, Chen M-R, Liang C-D, Chi H, Huang F-Y, Lee M-L, Huang Y-C, Hwang B, Chiu N-C, Hwang K-P, Lee P-C, Chang L-C, Liu Y-M, Chen Y-J, Chen C-H, Taiwan Pediatric ID Alliance, Chen Y-T, Tsai F-J, Wu J-Y. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet. 2012 Mar 25;44(5):522–525.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

March 25, 2012

Volume

44

Issue

5

Start / End Page

522 / 525

Location

United States

Related Subject Headings

  • Taiwan
  • Polymorphism, Single Nucleotide
  • Mucocutaneous Lymph Node Syndrome
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Genetic Markers
  • Genetic Loci
  • Developmental Biology
  • Case-Control Studies