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Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.

Publication ,  Journal Article
Kato, N; Takeuchi, F; Tabara, Y; Kelly, TN; Go, MJ; Sim, X; Tay, WT; Chen, C-H; Zhang, Y; Yamamoto, K; Katsuya, T; Yokota, M; Kim, YJ; Gu, D ...
Published in: Nat Genet
June 2011

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

June 2011

Volume

43

Issue

6

Start / End Page

531 / 538

Location

United States

Related Subject Headings

  • White People
  • Systole
  • Polymorphism, Single Nucleotide
  • Humans
  • Genome-Wide Association Study
  • Gene Frequency
  • Diastole
  • Developmental Biology
  • Blood Pressure
  • Asian People
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kato, N., Takeuchi, F., Tabara, Y., Kelly, T. N., Go, M. J., Sim, X., … He, J. (2011). Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet, 43(6), 531–538. https://doi.org/10.1038/ng.834
Kato, Norihiro, Fumihiko Takeuchi, Yasuharu Tabara, Tanika N. Kelly, Min Jin Go, Xueling Sim, Wan Ting Tay, et al. “Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.Nat Genet 43, no. 6 (June 2011): 531–38. https://doi.org/10.1038/ng.834.
Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011 Jun;43(6):531–8.
Kato, Norihiro, et al. “Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.Nat Genet, vol. 43, no. 6, June 2011, pp. 531–38. Pubmed, doi:10.1038/ng.834.
Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen C-H, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RTH, Nabika T, Gu D, Chang L-C, Kokubo Y, Huang W, Ohnaka K, Yamori Y, Nakashima E, Jaquish CE, Lee J-Y, Seielstad M, Isono M, Hixson JE, Chen Y-T, Miki T, Zhou X, Sugiyama T, Jeon J-P, Liu JJ, Takayanagi R, Kim SS, Aung T, Sung YJ, Zhang X, Wong TY, Han B-G, Kobayashi S, Ogihara T, Zhu D, Iwai N, Wu J-Y, Teo YY, Tai ES, Cho YS, He J. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011 Jun;43(6):531–538.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

June 2011

Volume

43

Issue

6

Start / End Page

531 / 538

Location

United States

Related Subject Headings

  • White People
  • Systole
  • Polymorphism, Single Nucleotide
  • Humans
  • Genome-Wide Association Study
  • Gene Frequency
  • Diastole
  • Developmental Biology
  • Blood Pressure
  • Asian People