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Pharmacogenetics of toxic epidermal necrolysis.

Publication ,  Journal Article
Lee, MTM; Hung, S-I; Wei, C-Y; Chen, Y-T
Published in: Expert Opin Pharmacother
September 2010

IMPORTANCE OF THE FIELD: Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are two of the most severe drug-induced cutaneous reactions. Advances in genome technologies have allowed researchers to identify genetic markers associated with this drug-associated event and these have provided a potential tool for prevention. AREAS COVERED IN THIS REVIEW: Current updates of genetic biomarkers that have been identified as being associated with TEN/SJS induced by several drugs, and the associations of these markers in different populations, are discussed. WHAT THE READER WILL GAIN: The strong association of HLA-B*1502 and carbamazepine (CBZ)-induced TEN/SJS have been reported by several independent studies. This association was mostly observed in patients of Southeast Asian ancestry; it was not observed in populations with low HLA-B*1502 allele frequency. Studies also suggest that drugs with a similar chemical structure to CBZ might also induce TEN/SJS in patients with HLA-B*1502. In addition to CBZ, HLA-B*5801 was also found to associate with allopurinol-induced TEN/SJS. This strongly suggests that the associations of these markers with TEN/SJS are drug specific. TAKE HOME MESSAGE: The strong association between CBZ and HLA-B*1502 has prompted the US Food and Drug Administration to update the label for CBZ to include genetic information and to recommend genetic testing before prescribing CBZ. Patients with Asian ancestry or who are from regions prevalent in HLA-B*1502 should be screened before CBZ treatment.

Duke Scholars

Published In

Expert Opin Pharmacother

DOI

EISSN

1744-7666

Publication Date

September 2010

Volume

11

Issue

13

Start / End Page

2153 / 2162

Location

England

Related Subject Headings

  • Stevens-Johnson Syndrome
  • Pharmacology & Pharmacy
  • Humans
  • HLA-B Antigens
  • Genetic Predisposition to Disease
  • Genetic Markers
  • Genes, MHC Class I
  • Gene Frequency
  • Drug-Related Side Effects and Adverse Reactions
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

APA
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MLA
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Lee, M. T. M., Hung, S.-I., Wei, C.-Y., & Chen, Y.-T. (2010). Pharmacogenetics of toxic epidermal necrolysis. Expert Opin Pharmacother, 11(13), 2153–2162. https://doi.org/10.1517/14656566.2010.495120
Lee, Ming Ta Michael, Shuen-Iu Hung, Chun-Yu Wei, and Yuan-Tsong Chen. “Pharmacogenetics of toxic epidermal necrolysis.Expert Opin Pharmacother 11, no. 13 (September 2010): 2153–62. https://doi.org/10.1517/14656566.2010.495120.
Lee MTM, Hung S-I, Wei C-Y, Chen Y-T. Pharmacogenetics of toxic epidermal necrolysis. Expert Opin Pharmacother. 2010 Sep;11(13):2153–62.
Lee, Ming Ta Michael, et al. “Pharmacogenetics of toxic epidermal necrolysis.Expert Opin Pharmacother, vol. 11, no. 13, Sept. 2010, pp. 2153–62. Pubmed, doi:10.1517/14656566.2010.495120.
Lee MTM, Hung S-I, Wei C-Y, Chen Y-T. Pharmacogenetics of toxic epidermal necrolysis. Expert Opin Pharmacother. 2010 Sep;11(13):2153–2162.

Published In

Expert Opin Pharmacother

DOI

EISSN

1744-7666

Publication Date

September 2010

Volume

11

Issue

13

Start / End Page

2153 / 2162

Location

England

Related Subject Headings

  • Stevens-Johnson Syndrome
  • Pharmacology & Pharmacy
  • Humans
  • HLA-B Antigens
  • Genetic Predisposition to Disease
  • Genetic Markers
  • Genes, MHC Class I
  • Gene Frequency
  • Drug-Related Side Effects and Adverse Reactions
  • 3214 Pharmacology and pharmaceutical sciences