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VKORC1 haplotypes in five East-Asian populations and Indians.

Publication ,  Journal Article
Lee, MTM; Chen, C-H; Chuang, H-P; Lu, L-S; Chou, C-H; Chen, Y-T; Liu, C-Y; Wen, M-S; Lu, J-J; Chang, C-F; Wu, J-Y; Chen, Y-T
Published in: Pharmacogenomics
October 2009

AIMS: Warfarin, a widely prescribed oral anticoagulant, is used for the prevention of thromboembolism. Several polymorphisms in VKORC1 have been shown to be associated with warfarin dose requirements. The frequencies of these VKORC1 polymorphisms display population differences; however, this has not been examined in many populations. In this study, we examined VKORC1 polymorphisms in five East-Asian populations (Han Chinese, Indonesian, Filipino, Thai and Vietnamese) and Indians. MATERIALS & METHODS: A total of six SNPs in the VKORC1 gene (-1639G>A, 497T>G, 1173C>T, 1542T>G, 2255C>T and 3730G>A) were genotyped. Frequencies, linkage disequilibrium and haplotype structures of these six VKORC1 SNPs were analyzed. RESULTS: Our data showed that 497T>G is only polymorphic in the Indian population. The 497G allele is very rare in the East-Asian populations (frequency < 1%). The remaining SNPs demonstrated high linkage disequilibrium and had similar frequencies and haplotype structures in all but the Indian population. The Indian population is mostly made up of the H7 haplotype (76%) while the rest of the recruited populations consisted of the H1 haplotype (> 80%).

Duke Scholars

Published In

Pharmacogenomics

DOI

EISSN

1744-8042

Publication Date

October 2009

Volume

10

Issue

10

Start / End Page

1609 / 1616

Location

England

Related Subject Headings

  • Warfarin
  • Vitamin K Epoxide Reductases
  • Vietnam
  • Thailand
  • Racial Groups
  • Polymorphism, Single Nucleotide
  • Philippines
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Mixed Function Oxygenases
 

Citation

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Chicago
ICMJE
MLA
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Lee, M. T. M., Chen, C.-H., Chuang, H.-P., Lu, L.-S., Chou, C.-H., Chen, Y.-T., … Wu, J.-Y. (2009). VKORC1 haplotypes in five East-Asian populations and Indians. Pharmacogenomics, 10(10), 1609–1616. https://doi.org/10.2217/pgs.09.80
Lee, Ming Ta Michael, Chien-Hsiun Chen, Hui-Ping Chuang, Liang-Suei Lu, Ching-Heng Chou, Ying-Ting Chen, Chih-Yang Liu, et al. “VKORC1 haplotypes in five East-Asian populations and Indians.Pharmacogenomics 10, no. 10 (October 2009): 1609–16. https://doi.org/10.2217/pgs.09.80.
Lee MTM, Chen C-H, Chuang H-P, Lu L-S, Chou C-H, Chen Y-T, et al. VKORC1 haplotypes in five East-Asian populations and Indians. Pharmacogenomics. 2009 Oct;10(10):1609–16.
Lee, Ming Ta Michael, et al. “VKORC1 haplotypes in five East-Asian populations and Indians.Pharmacogenomics, vol. 10, no. 10, Oct. 2009, pp. 1609–16. Pubmed, doi:10.2217/pgs.09.80.
Lee MTM, Chen C-H, Chuang H-P, Lu L-S, Chou C-H, Chen Y-T, Liu C-Y, Wen M-S, Lu J-J, Chang C-F, Wu J-Y. VKORC1 haplotypes in five East-Asian populations and Indians. Pharmacogenomics. 2009 Oct;10(10):1609–1616.
Journal cover image

Published In

Pharmacogenomics

DOI

EISSN

1744-8042

Publication Date

October 2009

Volume

10

Issue

10

Start / End Page

1609 / 1616

Location

England

Related Subject Headings

  • Warfarin
  • Vitamin K Epoxide Reductases
  • Vietnam
  • Thailand
  • Racial Groups
  • Polymorphism, Single Nucleotide
  • Philippines
  • Pharmacology & Pharmacy
  • Pharmacogenetics
  • Mixed Function Oxygenases