Skip to main content
Journal cover image

Testing homogeneity of two zero-inflated Poisson populations.

Publication ,  Journal Article
Tse, SK; Chow, SC; Lu, Q; Cosmatos, D
Published in: Biom J
February 2009

The problem of testing treatment difference in the occurrence of a safety parameter in a randomized parallel-group comparative clinical trial under the assumption that the number of occurrence follows a zero-inflated Poisson (ZIP) distribution is considered. Likelihood ratio tests (LRT) for homogeneity of two ZIP populations are derived under the hypotheses that (i) there is no difference in inflation parameters, (ii) there is no difference in non-zero means; and (iii) there is no difference in both inflation parameters and non-zero means. Approximate formulas for sample size calculation are also obtained for achieving a desired power for detecting a clinically meaningful difference under the corresponding alternative hypotheses. An example concerning the assessment of the gastrointestinal (GI) safety in terms of the number of erosion counts of a newly developed compound for the treatment of osteoarthritis and rheumatoid arthritis is given for illustration purpose.

Duke Scholars

Published In

Biom J

DOI

EISSN

1521-4036

Publication Date

February 2009

Volume

51

Issue

1

Start / End Page

159 / 170

Location

Germany

Related Subject Headings

  • Statistics & Probability
  • Risk Factors
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Poisson Distribution
  • Outcome Assessment, Health Care
  • Models, Statistical
  • Epidemiologic Methods
  • Endpoint Determination
  • Data Interpretation, Statistical
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tse, S. K., Chow, S. C., Lu, Q., & Cosmatos, D. (2009). Testing homogeneity of two zero-inflated Poisson populations. Biom J, 51(1), 159–170. https://doi.org/10.1002/bimj.200710490
Tse, Siu Keung, Shein Chung Chow, Qingshu Lu, and Dennis Cosmatos. “Testing homogeneity of two zero-inflated Poisson populations.Biom J 51, no. 1 (February 2009): 159–70. https://doi.org/10.1002/bimj.200710490.
Tse SK, Chow SC, Lu Q, Cosmatos D. Testing homogeneity of two zero-inflated Poisson populations. Biom J. 2009 Feb;51(1):159–70.
Tse, Siu Keung, et al. “Testing homogeneity of two zero-inflated Poisson populations.Biom J, vol. 51, no. 1, Feb. 2009, pp. 159–70. Pubmed, doi:10.1002/bimj.200710490.
Tse SK, Chow SC, Lu Q, Cosmatos D. Testing homogeneity of two zero-inflated Poisson populations. Biom J. 2009 Feb;51(1):159–170.
Journal cover image

Published In

Biom J

DOI

EISSN

1521-4036

Publication Date

February 2009

Volume

51

Issue

1

Start / End Page

159 / 170

Location

Germany

Related Subject Headings

  • Statistics & Probability
  • Risk Factors
  • Risk Assessment
  • Randomized Controlled Trials as Topic
  • Poisson Distribution
  • Outcome Assessment, Health Care
  • Models, Statistical
  • Epidemiologic Methods
  • Endpoint Determination
  • Data Interpretation, Statistical