Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents.
Publication
, Journal Article
Jiang, JB; Johnson, MG; Defauw, JM; Beine, TM; Ballas, LM; Janzen, WP; Loomis, CR; Seldin, J; Cofield, D; Adams, L
Published in: J Med Chem
November 13, 1992
A novel series of diaminoanthraquinones was discovered initially as protein kinase C inhibitors with IC50s in the 50-100 microM range. They exhibited potent tumor cell growth inhibitory activity in vitro without cross resistance to adriamycin. Further evaluation of two of the most active compounds NSC 639365 (3) and NSC 639366 (4) in human tumor cloning assay showed potent cytocidal activity. The results suggest therapeutical potentials against human tumors.
Duke Scholars
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Published In
J Med Chem
DOI
ISSN
0022-2623
Publication Date
November 13, 1992
Volume
35
Issue
23
Start / End Page
4259 / 4263
Location
United States
Related Subject Headings
- Tumor Stem Cell Assay
- Tumor Cells, Cultured
- Protein Kinase C
- Medicinal & Biomolecular Chemistry
- Humans
- Cell Division
- Antineoplastic Agents
- Anthraquinones
- 1115 Pharmacology and Pharmaceutical Sciences
- 0305 Organic Chemistry
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Jiang, J. B., Johnson, M. G., Defauw, J. M., Beine, T. M., Ballas, L. M., Janzen, W. P., … Adams, L. (1992). Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents. J Med Chem, 35(23), 4259–4263. https://doi.org/10.1021/jm00101a001
Jiang, J. B., M. G. Johnson, J. M. Defauw, T. M. Beine, L. M. Ballas, W. P. Janzen, C. R. Loomis, J. Seldin, D. Cofield, and L. Adams. “Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents.” J Med Chem 35, no. 23 (November 13, 1992): 4259–63. https://doi.org/10.1021/jm00101a001.
Jiang JB, Johnson MG, Defauw JM, Beine TM, Ballas LM, Janzen WP, et al. Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents. J Med Chem. 1992 Nov 13;35(23):4259–63.
Jiang, J. B., et al. “Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents.” J Med Chem, vol. 35, no. 23, Nov. 1992, pp. 4259–63. Pubmed, doi:10.1021/jm00101a001.
Jiang JB, Johnson MG, Defauw JM, Beine TM, Ballas LM, Janzen WP, Loomis CR, Seldin J, Cofield D, Adams L. Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents. J Med Chem. 1992 Nov 13;35(23):4259–4263.
Published In
J Med Chem
DOI
ISSN
0022-2623
Publication Date
November 13, 1992
Volume
35
Issue
23
Start / End Page
4259 / 4263
Location
United States
Related Subject Headings
- Tumor Stem Cell Assay
- Tumor Cells, Cultured
- Protein Kinase C
- Medicinal & Biomolecular Chemistry
- Humans
- Cell Division
- Antineoplastic Agents
- Anthraquinones
- 1115 Pharmacology and Pharmaceutical Sciences
- 0305 Organic Chemistry