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The clinical utility index as a practical multiattribute approach to drug development decisions.

Publication ,  Journal Article
Poland, B; Hodge, FL; Khan, A; Clemen, RT; Wagner, JA; Dykstra, K; Krishna, R
Published in: Clinical pharmacology and therapeutics
July 2009

We identify some innovative approaches to predicting overall patient benefit from investigational drugs to support development decisions. We then illustrate calculation of a probabilistic clinical utility index (CUI), an implementation of multiattribute utility that focuses on clinical attributes. We recommend use of the CUI for the support of early drug development decisions because of its practicality, reasonable accuracy, and transparency to decision makers, at stages in which financial factors that may dominate later-phase decisions are less critical.

Duke Scholars

Published In

Clinical pharmacology and therapeutics

DOI

EISSN

1532-6535

ISSN

0009-9236

Publication Date

July 2009

Volume

86

Issue

1

Start / End Page

105 / 108

Related Subject Headings

  • Pharmacology & Pharmacy
  • Humans
  • Drug Industry
  • Drug Discovery
  • Decision Making
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Poland, B., Hodge, F. L., Khan, A., Clemen, R. T., Wagner, J. A., Dykstra, K., & Krishna, R. (2009). The clinical utility index as a practical multiattribute approach to drug development decisions. Clinical Pharmacology and Therapeutics, 86(1), 105–108. https://doi.org/10.1038/clpt.2009.71
Poland, B., F. L. Hodge, A. Khan, R. T. Clemen, J. A. Wagner, K. Dykstra, and R. Krishna. “The clinical utility index as a practical multiattribute approach to drug development decisions.Clinical Pharmacology and Therapeutics 86, no. 1 (July 2009): 105–8. https://doi.org/10.1038/clpt.2009.71.
Poland B, Hodge FL, Khan A, Clemen RT, Wagner JA, Dykstra K, et al. The clinical utility index as a practical multiattribute approach to drug development decisions. Clinical pharmacology and therapeutics. 2009 Jul;86(1):105–8.
Poland, B., et al. “The clinical utility index as a practical multiattribute approach to drug development decisions.Clinical Pharmacology and Therapeutics, vol. 86, no. 1, July 2009, pp. 105–08. Epmc, doi:10.1038/clpt.2009.71.
Poland B, Hodge FL, Khan A, Clemen RT, Wagner JA, Dykstra K, Krishna R. The clinical utility index as a practical multiattribute approach to drug development decisions. Clinical pharmacology and therapeutics. 2009 Jul;86(1):105–108.
Journal cover image

Published In

Clinical pharmacology and therapeutics

DOI

EISSN

1532-6535

ISSN

0009-9236

Publication Date

July 2009

Volume

86

Issue

1

Start / End Page

105 / 108

Related Subject Headings

  • Pharmacology & Pharmacy
  • Humans
  • Drug Industry
  • Drug Discovery
  • Decision Making
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences