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Renal actions of RGS2 control blood pressure.

Publication ,  Journal Article
Gurley, SB; Griffiths, RC; Mendelsohn, ME; Karas, RH; Coffman, TM
Published in: J Am Soc Nephrol
November 2010

G protein-coupled receptors (GPCRs) have key roles in cardiovascular regulation and are important targets for the treatment of hypertension. GTPase-activating proteins, such as RGS2, modulate downstream signaling by GPCRs. RGS2 displays regulatory selectivity for the Gαq subclass of G proteins, and mice lacking RGS2 develop hypertension through incompletely understood mechanisms. Using total body RGS2-deficient mice, we used a kidney crosstransplantation strategy to examine separately the contributions of RGS2 actions in the kidney from those in extrarenal tissues with regard to BP regulation. Loss of renal RGS2 was sufficient to cause hypertension, whereas the absence of RGS2 from all extrarenal tissues including the peripheral vasculature did not significantly alter BP. Accordingly, these results suggest that RGS2 acts within the kidney to modulate BP and prevent hypertension. These data support a critical role for the renal epithelium and/or vasculature as the final determinants of the intra-arterial pressure in hypertension.

Duke Scholars

Published In

J Am Soc Nephrol

DOI

EISSN

1533-3450

Publication Date

November 2010

Volume

21

Issue

11

Start / End Page

1847 / 1851

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Receptors, G-Protein-Coupled
  • RGS Proteins
  • Mice, Knockout
  • Mice
  • Male
  • Kidney Transplantation
  • Kidney
  • Hypertension
  • Disease Models, Animal
 

Citation

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Gurley, S. B., Griffiths, R. C., Mendelsohn, M. E., Karas, R. H., & Coffman, T. M. (2010). Renal actions of RGS2 control blood pressure. J Am Soc Nephrol, 21(11), 1847–1851. https://doi.org/10.1681/ASN.2009121306
Gurley, Susan B., Robert C. Griffiths, Michael E. Mendelsohn, Richard H. Karas, and Thomas M. Coffman. “Renal actions of RGS2 control blood pressure.J Am Soc Nephrol 21, no. 11 (November 2010): 1847–51. https://doi.org/10.1681/ASN.2009121306.
Gurley SB, Griffiths RC, Mendelsohn ME, Karas RH, Coffman TM. Renal actions of RGS2 control blood pressure. J Am Soc Nephrol. 2010 Nov;21(11):1847–51.
Gurley, Susan B., et al. “Renal actions of RGS2 control blood pressure.J Am Soc Nephrol, vol. 21, no. 11, Nov. 2010, pp. 1847–51. Pubmed, doi:10.1681/ASN.2009121306.
Gurley SB, Griffiths RC, Mendelsohn ME, Karas RH, Coffman TM. Renal actions of RGS2 control blood pressure. J Am Soc Nephrol. 2010 Nov;21(11):1847–1851.

Published In

J Am Soc Nephrol

DOI

EISSN

1533-3450

Publication Date

November 2010

Volume

21

Issue

11

Start / End Page

1847 / 1851

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Receptors, G-Protein-Coupled
  • RGS Proteins
  • Mice, Knockout
  • Mice
  • Male
  • Kidney Transplantation
  • Kidney
  • Hypertension
  • Disease Models, Animal