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Essential role of AT1A receptor in the development of 2K1C hypertension.

Publication ,  Journal Article
Cervenka, L; Horácek, V; Vanecková, I; Hubácek, JA; Oliverio, MI; Coffman, TM; Navar, LG
Published in: Hypertension
November 2002

The aims of this study were to delineate the relative contribution of angiotensin II (ANG II) subtype 1A (AT1A) and 1B (AT1B) receptors to the development of two-kidney, one-clip (2K1C) Goldblatt hypertension in mice, to examine if increased nitric oxide synthase (NOS) activity counteracts the vasoconstrictor influences of ANG II in 2K1C hypertensive mice, and to determine the role of ANG II type 2 (AT2) receptors in 2K1C hypertension in mice. AT(1A) ANG II receptor knockout (AT1A-/-) and wild-type (AT1A+/+) mice underwent clipping of the right renal artery. Systolic blood pressure (SBP) was significantly lower in AT1A-/- compared with AT1A+/+ mice, and neither clip placement nor AT2 receptor blockade with PD 123319 (PD) altered SBP in AT1A-/- mice. A significant and sustained rise in SBP from 119+/-5 to 163+/-6 mm Hg was observed in the 2K1C AT1A+/+ mice from day 10 to day 26. Chronic PD infusion did not alter the course of hypertension in 2K1C/AT1A+/+. Acute PD infusion did not alter mean arterial pressure (MAP) in AT1A+/+, PD/AT1A+/+, 2K1C/AT1A+/+, PD/2K1C/AT1A+/+, AT1A-/-, PD/AT1A-/-, and PD/2K1C/AT1A-/- mice compared with basal levels. In contrast, acute PD infusion caused significant increases in MAP in 2K1C/AT1A-/- mice. The subsequent acute NOS inhibition caused greater increases in MAP in 2K1C/AT1A+/+ and PD/2K1C/AT1A+/+ mice than in AT1A+/+ and PD/AT1A+/+ mice. These results support the essential role of AT1A receptors in mediating 2K1C hypertension and support the hypothesis that augmented NO production serves as a counteracting system in this model of hypertension.

Duke Scholars

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

November 2002

Volume

40

Issue

5

Start / End Page

735 / 741

Location

United States

Related Subject Headings

  • Receptors, Angiotensin
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Pyridines
  • Organ Size
  • Nitric Oxide Synthase
  • Myocardium
  • Mice, Knockout
  • Mice
  • Male
 

Citation

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Cervenka, L., Horácek, V., Vanecková, I., Hubácek, J. A., Oliverio, M. I., Coffman, T. M., & Navar, L. G. (2002). Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension, 40(5), 735–741. https://doi.org/10.1161/01.hyp.0000036452.28493.74
Cervenka, Ludek, Vladislav Horácek, Ivana Vanecková, Jaroslav A. Hubácek, Michael I. Oliverio, Thomas M. Coffman, and L Gabriel Navar. “Essential role of AT1A receptor in the development of 2K1C hypertension.Hypertension 40, no. 5 (November 2002): 735–41. https://doi.org/10.1161/01.hyp.0000036452.28493.74.
Cervenka L, Horácek V, Vanecková I, Hubácek JA, Oliverio MI, Coffman TM, et al. Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension. 2002 Nov;40(5):735–41.
Cervenka, Ludek, et al. “Essential role of AT1A receptor in the development of 2K1C hypertension.Hypertension, vol. 40, no. 5, Nov. 2002, pp. 735–41. Pubmed, doi:10.1161/01.hyp.0000036452.28493.74.
Cervenka L, Horácek V, Vanecková I, Hubácek JA, Oliverio MI, Coffman TM, Navar LG. Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension. 2002 Nov;40(5):735–741.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

November 2002

Volume

40

Issue

5

Start / End Page

735 / 741

Location

United States

Related Subject Headings

  • Receptors, Angiotensin
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Pyridines
  • Organ Size
  • Nitric Oxide Synthase
  • Myocardium
  • Mice, Knockout
  • Mice
  • Male