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Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study.

Publication ,  Journal Article
Wadley, VG; Crowe, M; Marsiske, M; Cook, SE; Unverzagt, FW; Rosenberg, AL; Rexroth, D
Published in: J Am Geriatr Soc
August 2007

OBJECTIVES: To examine trajectories of change in everyday function for individuals with cognitive deficits suggestive of mild cognitive impairment (MCI). DESIGN: Using data from the longitudinal, multisite Advanced Cognitive Training for Independent and Vital Elderly Study allowed for post hoc classification of MCI status at baseline using psychometric definitions for amnestic MCI, nonamnestic MCI, multidomain MCI, and no MCI. SETTING: Six U.S. cities. PARTICIPANTS: Two thousand eight hundred thirty-two volunteers (mean age 74; 26% African American) living independently, recruited from senior housing, community centers, hospitals, and clinics. MEASUREMENTS: Mixed-effect models examined changes in self-reported activities of daily living and instrumental activities of daily living (IADLs) from the Minimum Data Set Home Care Interview in 2,358 participants over a 3-year period. RESULTS: In models for IADL performance, IADL difficulty, and a daily functioning composite, there was a significant time by MCI classification interaction for each MCI subtype, indicating that all MCI groups showed faster rates of decline in everyday function than cognitively normal participants with no MCI. CONCLUSION: Results demonstrate the importance of MCI as a clinical entity that not only predicts progression to dementia, but also predicts functional declines in activities that are key to autonomy and quality of life. MCI classification guidelines should allow for functional changes in MCI, and clinicians should monitor for such changes. Preservation of function may serve as a meaningful outcome for intervention efforts.

Duke Scholars

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

August 2007

Volume

55

Issue

8

Start / End Page

1192 / 1198

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Psychometrics
  • Male
  • Humans
  • Geriatrics
  • Female
  • Cognition Disorders
  • Aged
  • Activities of Daily Living
  • 52 Psychology
 

Citation

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Wadley, V. G., Crowe, M., Marsiske, M., Cook, S. E., Unverzagt, F. W., Rosenberg, A. L., & Rexroth, D. (2007). Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study. J Am Geriatr Soc, 55(8), 1192–1198. https://doi.org/10.1111/j.1532-5415.2007.01245.x
Wadley, Virginia G., Michael Crowe, Michael Marsiske, Sarah E. Cook, Frederick W. Unverzagt, Adrienne L. Rosenberg, and Daniel Rexroth. “Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study.J Am Geriatr Soc 55, no. 8 (August 2007): 1192–98. https://doi.org/10.1111/j.1532-5415.2007.01245.x.
Wadley VG, Crowe M, Marsiske M, Cook SE, Unverzagt FW, Rosenberg AL, et al. Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study. J Am Geriatr Soc. 2007 Aug;55(8):1192–8.
Wadley, Virginia G., et al. “Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study.J Am Geriatr Soc, vol. 55, no. 8, Aug. 2007, pp. 1192–98. Pubmed, doi:10.1111/j.1532-5415.2007.01245.x.
Wadley VG, Crowe M, Marsiske M, Cook SE, Unverzagt FW, Rosenberg AL, Rexroth D. Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study. J Am Geriatr Soc. 2007 Aug;55(8):1192–1198.
Journal cover image

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

August 2007

Volume

55

Issue

8

Start / End Page

1192 / 1198

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Psychometrics
  • Male
  • Humans
  • Geriatrics
  • Female
  • Cognition Disorders
  • Aged
  • Activities of Daily Living
  • 52 Psychology