Telavancin for the treatment of serious gram-positive infections, including hospital acquired pneumonia.
INTRODUCTION: Hospital-acquired pneumonia is a common infection, associated with substantial mortality. Despite the increasing prevalence of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA), approved treatment options for this pathogen are limited. AREAS COVERED: This article reviews the pharmacokinetics, dosing, preclinical studies and clinical efficacy, and safety of telavancin, with a particular focus on results from trials in nosocomial pneumonia. PubMed and Congress websites were searched for relevant articles published between 2003 and 2010. EXPERT OPINION: Telavancin is a lipoglycopeptide antibiotic with rapid, bactericidal activity against MRSA, and may provide another option for the treatment of nosocomial pneumonia, owing to Gram-positive pathogens.
Duke Scholars
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Related Subject Headings
- Skin Diseases, Bacterial
- Pneumonia, Staphylococcal
- Pharmacology & Pharmacy
- Methicillin-Resistant Staphylococcus aureus
- Lipoglycopeptides
- Humans
- Gram-Positive Bacterial Infections
- Cross Infection
- Anti-Bacterial Agents
- Animals
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Skin Diseases, Bacterial
- Pneumonia, Staphylococcal
- Pharmacology & Pharmacy
- Methicillin-Resistant Staphylococcus aureus
- Lipoglycopeptides
- Humans
- Gram-Positive Bacterial Infections
- Cross Infection
- Anti-Bacterial Agents
- Animals