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Drug treatment of microsporidiosis.

Publication ,  Journal Article
Costa, SF; Weiss, LM
Published in: Drug Resist Updat
December 2000

Microsporidia are ubiquitous organisms that are emerging pathogens in humans. These are most likely zoonotic and/or waterborne infections. In the immunosuppressed host, such as those treated with immunosuppressive drugs or infected with human immunodeficiency virus particularly at advanced stages of the disease, microsporidia can produce a wide range of clinical diseases. The most common manifestation is gastrointestinal tract infection; however, encephalitis, ocular infection, sinusitis, myositis and disseminated infection have also been described. In addition, these organisms have been reported in immune competent individuals. Multiple genera are involved in these infections and different organisms can result in distinct clinical pictures. Differences in clinical and parasitologic response to various therapeutic agents have emerged from clinical, as well as in vitro and in vivo studies. Currently there are no precisely defined guidelines for the optimal treatment of microsporidial infections. This article reviews the available data on compounds with in vitro activity and/or in vivo efficacy for microsporidial infections. Copyright 2000 Harcourt Publishers Ltd.

Duke Scholars

Published In

Drug Resist Updat

DOI

EISSN

1532-2084

Publication Date

December 2000

Volume

3

Issue

6

Start / End Page

384 / 399

Location

Scotland

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Costa, S. F., & Weiss, L. M. (2000). Drug treatment of microsporidiosis. Drug Resist Updat, 3(6), 384–399. https://doi.org/10.1054/drup.2000.0174
Costa, Sylvia F., and Louis M. Weiss. “Drug treatment of microsporidiosis.Drug Resist Updat 3, no. 6 (December 2000): 384–99. https://doi.org/10.1054/drup.2000.0174.
Costa SF, Weiss LM. Drug treatment of microsporidiosis. Drug Resist Updat. 2000 Dec;3(6):384–99.
Costa, Sylvia F., and Louis M. Weiss. “Drug treatment of microsporidiosis.Drug Resist Updat, vol. 3, no. 6, Dec. 2000, pp. 384–99. Pubmed, doi:10.1054/drup.2000.0174.
Costa SF, Weiss LM. Drug treatment of microsporidiosis. Drug Resist Updat. 2000 Dec;3(6):384–399.
Journal cover image

Published In

Drug Resist Updat

DOI

EISSN

1532-2084

Publication Date

December 2000

Volume

3

Issue

6

Start / End Page

384 / 399

Location

Scotland

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3107 Microbiology
  • 3101 Biochemistry and cell biology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1108 Medical Microbiology
  • 0605 Microbiology