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Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes.

Publication ,  Journal Article
Glaspy, J; Crawford, J; Vansteenkiste, J; Henry, D; Rao, S; Bowers, P; Berlin, JA; Tomita, D; Bridges, K; Ludwig, H
Published in: Br J Cancer
January 19, 2010

BACKGROUND: Cancer patients often develop the potentially debilitating condition of anaemia. Numerous controlled studies indicate that erythropoiesis-stimulating agents (ESAs) can raise haemoglobin levels and reduce transfusion requirements in anaemic cancer patients receiving chemotherapy. To evaluate recent safety concerns regarding ESAs, we carried out a meta-analysis of controlled ESA oncology trials to examine whether ESA use affects survival, disease progression and risk of venous-thromboembolic events. METHODS: This meta-analysis included studies from the 2006 Cochrane meta-analysis, studies published/updated since the 2006 Cochrane report, and unpublished trial data from Amgen and Centocor Ortho Biotech. The 60 studies analysed (15 323 patients) were conducted in the settings of chemotherapy/radiochemotherapy, radiotherapy only treatment or anaemia of cancer. Data were summarised using odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: Results indicated that ESA use did not significantly affect mortality (60 studies: OR=1.06; 95% CI: 0.97-1.15) or disease progression (26 studies: OR=1.01; 95% CI: 0.90-1.14), but increased the risk for venous-thromoboembolic events (44 studies: OR=1.48; 95% CI: 1.28-1.72). CONCLUSION: Though this meta-analysis showed no significant effect of ESAs on survival or disease progression, prospectively designed, future randomised clinical trials will further examine the safety and efficacy of ESAs when used according to the revised labelling information.

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

January 19, 2010

Volume

102

Issue

2

Start / End Page

301 / 315

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Hematinics
  • Anemia
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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Glaspy, J., Crawford, J., Vansteenkiste, J., Henry, D., Rao, S., Bowers, P., … Ludwig, H. (2010). Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes. Br J Cancer, 102(2), 301–315. https://doi.org/10.1038/sj.bjc.6605498
Glaspy, J., J. Crawford, J. Vansteenkiste, D. Henry, S. Rao, P. Bowers, J. A. Berlin, D. Tomita, K. Bridges, and H. Ludwig. “Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes.Br J Cancer 102, no. 2 (January 19, 2010): 301–15. https://doi.org/10.1038/sj.bjc.6605498.
Glaspy J, Crawford J, Vansteenkiste J, Henry D, Rao S, Bowers P, et al. Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes. Br J Cancer. 2010 Jan 19;102(2):301–15.
Glaspy, J., et al. “Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes.Br J Cancer, vol. 102, no. 2, Jan. 2010, pp. 301–15. Pubmed, doi:10.1038/sj.bjc.6605498.
Glaspy J, Crawford J, Vansteenkiste J, Henry D, Rao S, Bowers P, Berlin JA, Tomita D, Bridges K, Ludwig H. Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes. Br J Cancer. 2010 Jan 19;102(2):301–315.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

January 19, 2010

Volume

102

Issue

2

Start / End Page

301 / 315

Location

England

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Hematinics
  • Anemia
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
  • 1112 Oncology and Carcinogenesis