Approximating selective sweeps.
Publication
, Journal Article
Durrett, R; Schweinsberg, J
Published in: Theoretical population biology
September 2004
The fixation of advantageous mutations in a population has the effect of reducing variation in the DNA sequence near that mutation. Kaplan et al. (1989) used a three-phase simulation model to study the effect of selective sweeps on genealogies. However, most subsequent work has simplified their approach by assuming that the number of individuals with the advantageous allele follows the logistic differential equation. We show that the impact of a selective sweep can be accurately approximated by a random partition created by a stick-breaking process. Our simulation results show that ignoring the randomness when the number of individuals with the advantageous allele is small can lead to substantial errors.
Duke Scholars
Published In
Theoretical population biology
DOI
EISSN
1096-0325
ISSN
0040-5809
Publication Date
September 2004
Volume
66
Issue
2
Start / End Page
129 / 138
Related Subject Headings
- Selection, Genetic
- Mutation
- Models, Genetic
- Humans
- Genetics, Population
- Evolutionary Biology
- Alleles
- 4901 Applied mathematics
- 3104 Evolutionary biology
- 3103 Ecology
Citation
APA
Chicago
ICMJE
MLA
NLM
Durrett, R., & Schweinsberg, J. (2004). Approximating selective sweeps. Theoretical Population Biology, 66(2), 129–138. https://doi.org/10.1016/j.tpb.2004.04.002
Durrett, Richard, and Jason Schweinsberg. “Approximating selective sweeps.” Theoretical Population Biology 66, no. 2 (September 2004): 129–38. https://doi.org/10.1016/j.tpb.2004.04.002.
Durrett R, Schweinsberg J. Approximating selective sweeps. Theoretical population biology. 2004 Sep;66(2):129–38.
Durrett, Richard, and Jason Schweinsberg. “Approximating selective sweeps.” Theoretical Population Biology, vol. 66, no. 2, Sept. 2004, pp. 129–38. Epmc, doi:10.1016/j.tpb.2004.04.002.
Durrett R, Schweinsberg J. Approximating selective sweeps. Theoretical population biology. 2004 Sep;66(2):129–138.
Published In
Theoretical population biology
DOI
EISSN
1096-0325
ISSN
0040-5809
Publication Date
September 2004
Volume
66
Issue
2
Start / End Page
129 / 138
Related Subject Headings
- Selection, Genetic
- Mutation
- Models, Genetic
- Humans
- Genetics, Population
- Evolutionary Biology
- Alleles
- 4901 Applied mathematics
- 3104 Evolutionary biology
- 3103 Ecology