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Approximating selective sweeps.

Publication ,  Journal Article
Durrett, R; Schweinsberg, J
Published in: Theoretical population biology
September 2004

The fixation of advantageous mutations in a population has the effect of reducing variation in the DNA sequence near that mutation. Kaplan et al. (1989) used a three-phase simulation model to study the effect of selective sweeps on genealogies. However, most subsequent work has simplified their approach by assuming that the number of individuals with the advantageous allele follows the logistic differential equation. We show that the impact of a selective sweep can be accurately approximated by a random partition created by a stick-breaking process. Our simulation results show that ignoring the randomness when the number of individuals with the advantageous allele is small can lead to substantial errors.

Duke Scholars

Published In

Theoretical population biology

DOI

EISSN

1096-0325

ISSN

0040-5809

Publication Date

September 2004

Volume

66

Issue

2

Start / End Page

129 / 138

Related Subject Headings

  • Selection, Genetic
  • Mutation
  • Models, Genetic
  • Humans
  • Genetics, Population
  • Evolutionary Biology
  • Alleles
  • 4901 Applied mathematics
  • 3104 Evolutionary biology
  • 3103 Ecology
 

Citation

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Durrett, R., & Schweinsberg, J. (2004). Approximating selective sweeps. Theoretical Population Biology, 66(2), 129–138. https://doi.org/10.1016/j.tpb.2004.04.002
Durrett, Richard, and Jason Schweinsberg. “Approximating selective sweeps.Theoretical Population Biology 66, no. 2 (September 2004): 129–38. https://doi.org/10.1016/j.tpb.2004.04.002.
Durrett R, Schweinsberg J. Approximating selective sweeps. Theoretical population biology. 2004 Sep;66(2):129–38.
Durrett, Richard, and Jason Schweinsberg. “Approximating selective sweeps.Theoretical Population Biology, vol. 66, no. 2, Sept. 2004, pp. 129–38. Epmc, doi:10.1016/j.tpb.2004.04.002.
Durrett R, Schweinsberg J. Approximating selective sweeps. Theoretical population biology. 2004 Sep;66(2):129–138.
Journal cover image

Published In

Theoretical population biology

DOI

EISSN

1096-0325

ISSN

0040-5809

Publication Date

September 2004

Volume

66

Issue

2

Start / End Page

129 / 138

Related Subject Headings

  • Selection, Genetic
  • Mutation
  • Models, Genetic
  • Humans
  • Genetics, Population
  • Evolutionary Biology
  • Alleles
  • 4901 Applied mathematics
  • 3104 Evolutionary biology
  • 3103 Ecology