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Distribution and abundance of microsatellites in the yeast genome can Be explained by a balance between slippage events and point mutations.

Publication ,  Journal Article
Kruglyak, S; Durrett, R; Schug, MD; Aquadro, CF
Published in: Molecular biology and evolution
August 2000

We fit a Markov chain model of microsatellite evolution introduced by Kruglyak et al. to data on all di-, tri-, and tetranucleotide repeats in the yeast genome. Our results suggest that many features of the distribution of abundance and length of microsatellites can be explained by this simple model, which incorporates a competition between slippage events and base pair substitutions, with no need to invoke selection or constraints on the lengths. Our results provide some new information on slippage rates for individual repeat motifs, which suggest that AT-rich trinucleotide repeats have higher slippage rates. As our model predicts, we found that many repeats were adjacent to shorter repeats of the same motif. However, we also found a significant tendency of microsatellites of different motifs to cluster.

Duke Scholars

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

August 2000

Volume

17

Issue

8

Start / End Page

1210 / 1219

Related Subject Headings

  • Trinucleotide Repeats
  • Saccharomyces cerevisiae
  • Point Mutation
  • Models, Genetic
  • Microsatellite Repeats
  • Markov Chains
  • Genome, Fungal
  • Evolutionary Biology
  • Dinucleotide Repeats
  • DNA, Fungal
 

Citation

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Kruglyak, S., Durrett, R., Schug, M. D., & Aquadro, C. F. (2000). Distribution and abundance of microsatellites in the yeast genome can Be explained by a balance between slippage events and point mutations. Molecular Biology and Evolution, 17(8), 1210–1219. https://doi.org/10.1093/oxfordjournals.molbev.a026404
Kruglyak, S., R. Durrett, M. D. Schug, and C. F. Aquadro. “Distribution and abundance of microsatellites in the yeast genome can Be explained by a balance between slippage events and point mutations.Molecular Biology and Evolution 17, no. 8 (August 2000): 1210–19. https://doi.org/10.1093/oxfordjournals.molbev.a026404.
Kruglyak S, Durrett R, Schug MD, Aquadro CF. Distribution and abundance of microsatellites in the yeast genome can Be explained by a balance between slippage events and point mutations. Molecular biology and evolution. 2000 Aug;17(8):1210–9.
Kruglyak, S., et al. “Distribution and abundance of microsatellites in the yeast genome can Be explained by a balance between slippage events and point mutations.Molecular Biology and Evolution, vol. 17, no. 8, Aug. 2000, pp. 1210–19. Epmc, doi:10.1093/oxfordjournals.molbev.a026404.
Kruglyak S, Durrett R, Schug MD, Aquadro CF. Distribution and abundance of microsatellites in the yeast genome can Be explained by a balance between slippage events and point mutations. Molecular biology and evolution. 2000 Aug;17(8):1210–1219.
Journal cover image

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

August 2000

Volume

17

Issue

8

Start / End Page

1210 / 1219

Related Subject Headings

  • Trinucleotide Repeats
  • Saccharomyces cerevisiae
  • Point Mutation
  • Models, Genetic
  • Microsatellite Repeats
  • Markov Chains
  • Genome, Fungal
  • Evolutionary Biology
  • Dinucleotide Repeats
  • DNA, Fungal