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Stromal gene signatures in large-B-cell lymphomas.

Publication ,  Journal Article
Lenz, G; Wright, G; Dave, SS; Xiao, W; Powell, J; Zhao, H; Xu, W; Tan, B; Goldschmidt, N; Iqbal, J; Vose, J; Bast, M; Fu, K; Greiner, TC ...
Published in: N Engl J Med
November 27, 2008

BACKGROUND: The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma. Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear. METHODS: We profiled gene expression in pretreatment biopsy specimens from 181 patients with diffuse large-B-cell lymphoma who received CHOP and 233 patients with this disease who received R-CHOP. A multivariate gene-expression-based survival-predictor model derived from a training group was tested in a validation group. RESULTS: A multivariate model created from three gene-expression signatures--termed "germinal-center B-cell," "stromal-1," and "stromal-2"--predicted survival both in patients who received CHOP and patients who received R-CHOP. The prognostically favorable stromal-1 signature reflected extracellular-matrix deposition and histiocytic infiltration. By contrast, the prognostically unfavorable stromal-2 signature reflected tumor blood-vessel density. CONCLUSIONS: Survival after treatment of diffuse large-B-cell lymphoma is influenced by differences in immune cells, fibrosis, and angiogenesis in the tumor microenvironment.

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Published In

N Engl J Med

DOI

EISSN

1533-4406

Publication Date

November 27, 2008

Volume

359

Issue

22

Start / End Page

2313 / 2323

Location

United States

Related Subject Headings

  • Vincristine
  • Stromal Cells
  • Rituximab
  • Prognosis
  • Prednisone
  • Neovascularization, Pathologic
  • Multivariate Analysis
  • Middle Aged
  • Lymphoma, Large B-Cell, Diffuse
  • Kaplan-Meier Estimate
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lenz, G., Wright, G., Dave, S. S., Xiao, W., Powell, J., Zhao, H., … Lymphoma/Leukemia Molecular Profiling Project, . (2008). Stromal gene signatures in large-B-cell lymphomas. The New England Journal of Medicine, 359(22), 2313–2323. https://doi.org/10.1056/nejmoa0802885
Lenz, G., G. Wright, S. S. Dave, W. Xiao, J. Powell, H. Zhao, W. Xu, et al. “Stromal gene signatures in large-B-cell lymphomas.The New England Journal of Medicine 359, no. 22 (November 2008): 2313–23. https://doi.org/10.1056/nejmoa0802885.
Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, et al. Stromal gene signatures in large-B-cell lymphomas. The New England journal of medicine. 2008 Nov;359(22):2313–23.
Lenz, G., et al. “Stromal gene signatures in large-B-cell lymphomas.The New England Journal of Medicine, vol. 359, no. 22, Nov. 2008, pp. 2313–23. Epmc, doi:10.1056/nejmoa0802885.
Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, Xu W, Tan B, Goldschmidt N, Iqbal J, Vose J, Bast M, Fu K, Weisenburger DD, Greiner TC, Armitage JO, Kyle A, May L, Gascoyne RD, Connors JM, Troen G, Holte H, Kvaloy S, Dierickx D, Verhoef G, Delabie J, Smeland EB, Jares P, Martinez A, Lopez-Guillermo A, Montserrat E, Campo E, Braziel RM, Miller TP, Rimsza LM, Cook JR, Pohlman B, Sweetenham J, Tubbs RR, Fisher RI, Hartmann E, Rosenwald A, Ott G, Muller-Hermelink H-K, Wrench D, Lister TA, Jaffe ES, Wilson WH, Chan WC, Staudt LM, Lymphoma/Leukemia Molecular Profiling Project. Stromal gene signatures in large-B-cell lymphomas. The New England journal of medicine. 2008 Nov;359(22):2313–2323.

Published In

N Engl J Med

DOI

EISSN

1533-4406

Publication Date

November 27, 2008

Volume

359

Issue

22

Start / End Page

2313 / 2323

Location

United States

Related Subject Headings

  • Vincristine
  • Stromal Cells
  • Rituximab
  • Prognosis
  • Prednisone
  • Neovascularization, Pathologic
  • Multivariate Analysis
  • Middle Aged
  • Lymphoma, Large B-Cell, Diffuse
  • Kaplan-Meier Estimate